Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.87 |
| ▸ | FGFR2 | P21802 | 16/20 | 0.87 |
| ▸ | FGFR4 | P22455 | 16/20 | 0.87 |
| ▸ | FGFR3 | P22607 | 16/20 | 0.87 |
| ▸ | FLT1 | P17948 | 11/20 | 0.87 |
| ▸ | FLT4 | P35916 | 11/20 | 0.87 |
| ▸ | KDR | P35968 | 11/20 | 0.87 |
| ▸ | SRC | P12931 | 3/20 | 0.87 |
| ▸ | GLA | P06280 | 1/20 | 0.87 |
| ▸ | CSK | P41240 | 1/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.87 |
| ▸ | ATM | Q13315 | 1/20 | 0.87 |
| ▸ | EGFR | P00533 | 3/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | PRKCG | P05129 | 1/20 | 0.60 |
| ▸ | PRKCB | P05771 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | PRKCH | P24723 | 1/20 | 0.60 |
| ▸ | PRKCI | P41743 | 1/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pd-173074 SCHEMBL29828472 | 0.93 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| Pd-173074 SCHEMBL177946 | 0.93 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL22144559 | 0.90 | FGFR1 (0.95) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL2470675 | 0.90 | FGFR1 (0.85) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL23224727 | 0.90 | FGFR1 (0.83) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL16489372 | 0.88 | FGFR1 (0.91) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL17814860 | 0.88 | FGFR1 (0.90) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL5619204 | 0.88 | FGFR1 (0.84) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL30737861 | 0.88 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3FLT1 | |
| SCHEMBL19848922 | 0.87 | FGFR1 (0.80) | FGFR1FGFR2FGFR4FGFR3FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263074-B2 | Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof | IMCLONE LLC (US) | 2012-09-11 | — | — | US | disclosed |
| US-20120121609-A1 | FIBROBLAST GROWTH FACTOR RECEPTOR-1 INHIBITORS AND METHODS OF TREATMENT THEREOF | IMCLONE LLC (US) | 2012-05-17 | — | — | US | disclosed |
| EP-2229955-A1 | Fibroblast growth factor receptor-1 inhibitors and methods of treatment using the same | Imclone LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| EP-2060270-A2 | Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof | IMCLONE SYSTEMS, INC. (US) | 2009-05-20 | — | — | EP | disclosed |
| EP-1680140-A4 | FIBROBLAST GROWTH FACTOR RECEPTOR-1 INHIBITORS AND METHODS OF TREATMENT THEREOF | IMCLONE SYSTEMS INC (US) | 2007-12-05 | — | — | EP | disclosed |
| US-20070274981-A1 | Fibroblast Growth Factor Receptor-1 Inhibitors and Methods of Treatment Thereof | IMCLONE SYSTEMS INCORPORATION (US) | 2007-11-29 | — | — | US | disclosed |
| US-20070274981-A1 | Fibroblast Growth Factor Receptor-1 Inhibitors and Methods of Treatment Thereof | IMCLONE SYSTEMS INCORPORATION (US) | 2007-11-29 | — | — | US | disclosed |
| EP-1680140-A2 | FIBROBLAST GROWTH FACTOR RECEPTOR-1 INHIBITORS AND METHODS OF TREATMENT THEREOF | IMCLONE SYSTEMS, INC. (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005037235-A2 | FIBROBLAST GROWTH FACTOR RECEPTOR-1 INHIBITORS AND METHODS OF TREATMENT THEREOF | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-28 | — | — | WO | disclosed |