Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3480824 | 0.88 | KCNA5 (0.57) | KCNA5KCNH2MAPK8KDM4EALDH1A1 | |
| SCHEMBL3480571 | 0.87 | KCNA5 (0.56) | KCNA5KCNH2MAPK8KDM4EALDH1A1 | |
| SCHEMBL1380146 | 0.83 | KCNA5 (0.52) | KCNA5KCNH2MAPK8KDM4EALDH1A1 | |
| SCHEMBL1376904 | 0.81 | KCNA5 (0.59) | KCNA5KCNH2MAPK8KDM4EALDH1A1 | |
| SCHEMBL1375623 | 0.78 | KCNA5 (0.56) | KCNA5KCNH2MAPK8KDM4EALDH1A1 | |
| SCHEMBL3623049 | 0.78 | KCNA5 (0.74) | KCNA5KCNH2MAPK8KDM4EALDH1A1 | |
| SCHEMBL3480659 | 0.74 | MAPK8 (0.71) | KCNA5KCNH2MAPK8TACR1 | |
| SCHEMBL4685991 | 0.74 | KCNA5 (0.61) | KCNA5KCNH2MAPK8TACR1KDM4E | |
| SCHEMBL5239049 | 0.73 | GRIA2 (0.48) | KCNA5KCNH2MAPK8TACR1KDM4E | |
| SCHEMBL5583193 | 0.72 | KCNA5 (0.67) | KCNA5KCNH2MAPK8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781457-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-08-24 | — | — | US | claimed |
| US-20060270704-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2006-11-30 | — | — | US | claimed |
| US-7781457-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781457-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781457-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20060270704-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270704-A1 | Isoquinolinone potassium channel inhibitors | KCNJ2, KCNQ1, KCNQ2 | KCNA5 21/4885KCNH2 5/4885MAPK8 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.