Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 5/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.75 |
| ▸ | GAA | P10253 | 4/20 | 0.75 |
| ▸ | GLA | P06280 | 3/20 | 0.75 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.75 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.75 |
| ▸ | ACHE | P22303 | 1/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.75 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.75 |
| ▸ | DRD3 | P35462 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | EHMT2 | Q96KQ7 | 11/20 | 0.47 |
| ▸ | EHMT1 | Q9H9B1 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3482471 | 0.92 | KCNH2 (0.79) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14340963 | 0.90 | KCNH2 (0.81) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL14564020 | 0.87 | KCNH2 (1.00) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| Alfuzosin SCHEMBL29355511 | 0.86 | KDM4E (1.00) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| Alfuzosin SCHEMBL2950056 | 0.86 | KDM4E (1.00) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| Alfuzosin SCHEMBL415972 | 0.86 | KDM4E (1.00) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| Alfuzosin SCHEMBL29497289 | 0.86 | KDM4E (1.00) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| Alfuzosin SCHEMBL34477 | 0.86 | KDM4E (1.00) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| Alfuzosin SCHEMBL4744369 | 0.85 | KDM4E (0.98) | KCNH2HPGDKDM4EALDH1A1HSD17B10 | |
| Alfuzosin SCHEMBL179910 | 0.85 | KDM4E (0.98) | KCNH2HPGDKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100174073-A1 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2010-07-08 | — | — | US | claimed |
| EP-2152697-A2 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | Actavis Group PTC EHF (IS) | 2010-02-17 | — | — | EP | claimed |
| WO-2008152514-A2 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2008-12-18 | — | — | WO | claimed |
| US-20100174073-A1 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2010-07-08 | — | — | US | disclosed |
| US-20100174073-A1 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2010-07-08 | — | — | US | disclosed |
| US-20100174073-A1 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2010-07-08 | — | — | US | disclosed |
| EP-2152697-A2 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | Actavis Group PTC EHF (IS) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008152514-A2 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152514-A2 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100174073-A1 | PROCESS FOR THE PREPARATION OF ALFUZOSIN AND SALTS THEREOF | AADAC, PTMS, LPXN | KCNH2 21/4885HPGD 744/4885KDM4E 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.