Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.57 |
| ▸ | VEGFA | P15692 | 5/20 | 0.48 |
| ▸ | FLT1 | P17948 | 5/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.48 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14331203 | 0.89 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL3484941 | 0.89 | EGLN1 (0.58) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3484715 | 0.89 | GRIN2B (0.51) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL3485418 | 0.89 | EGLN1 (0.63) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3484660 | 0.85 | EGLN1 (0.64) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3484979 | 0.84 | EGLN1 (0.60) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3485431 | 0.83 | EGLN1 (0.72) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3484350 | 0.83 | EGLN1 (0.58) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3485043 | 0.82 | EGLN1 (0.58) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3484817 | 0.82 | EGLN1 (0.57) | EGLN1VEGFAFLT1EGLN3TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331303-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. | 2010-12-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331303-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | HIF1AN, EGLN3, HIF1A | EGLN1 6/4885VEGFA 117/4885FLT1 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.