Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.46 |
| ▸ | VEGFA | P15692 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.45 |
| ▸ | ASPH | Q12797 | 1/20 | 0.45 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.45 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.45 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.45 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.45 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485401 | 0.90 | EGLN1 (0.48) | EGLN1GRIN2BGRIN1EGLN3VEGFA | |
| SCHEMBL3485322 | 0.89 | CNR2 (0.47) | EGLN1GRIN2BGRIN1EGLN3VEGFA | |
| SCHEMBL3485356 | 0.89 | EGLN1 (0.49) | EGLN1GRIN2BGRIN1EGLN3VEGFA | |
| SCHEMBL3485269 | 0.89 | GRIN2B (0.47) | EGLN1GRIN2BGRIN1EGLN3VEGFA | |
| SCHEMBL3485085 | 0.87 | GRIN2B (0.51) | EGLN1GRIN2BGRIN1EGLN3VEGFA | |
| SCHEMBL3485380 | 0.86 | EGLN1 (0.64) | EGLN1GRIN2BEGLN3VEGFAFLT1 | |
| SCHEMBL1921446 | 0.83 | EGLN1 (0.65) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL3484863 | 0.81 | EGLN1 (0.53) | EGLN1GRIN2BGRIN1EGLN3VEGFA | |
| SCHEMBL29056831 | 0.80 | EGLN1 (0.47) | EGLN1EGLN3VEGFAFLT1TET3 | |
| SCHEMBL1921240 | 0.80 | EGLN1 (0.75) | EGLN1EGLN3VEGFAFLT1TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160009648-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | KREOS CAPITAL VII (UK) LIMITED (GB) | 2016-01-14 | — | — | US | claimed |
| US-8343952-B2 | Prolyl hydroxylase inhibitors and methods of use | AKEBIA THERAPEUTICS INC. (US) | 2013-01-01 | — | — | US | claimed |
| US-20100331303-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. | 2010-12-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009648-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | HIF1AN, EGLN3, HIF1A | KDM4E 562/4885SMN1; SMN2 4157/4885EGLN1 6/4885 |
| US-20100331303-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | HIF1AN, EGLN3, HIF1A | KDM4E 562/4885SMN1; SMN2 4157/4885EGLN1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.