Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.60 |
| ▸ | PTGES | O14684 | 2/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | TOP2A | P11388 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | NT5E | P21589 | 4/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564481 | 0.94 | CETP (0.69) | CETPPRKCDPTGESPTPN1CES2 | |
| SCHEMBL564480 | 0.94 | CETP (0.69) | CETPPRKCDPTGESPTPN1CES2 | |
| SCHEMBL6741284 | 0.88 | PRKCD (0.75) | CETPPRKCDPTGESPTPN1CES2 | |
| Lupeol Linoleate SCHEMBL935903 | 0.87 | CETP (0.61) | CETPPRKCDPTGESPTPN1CES2 | |
| Lupeol Linoleate SCHEMBL935900 | 0.87 | CETP (0.61) | CETPPRKCDPTGESPTPN1CES2 | |
| SCHEMBL15496672 | 0.87 | CETP (0.69) | CETPPRKCDPTGESPTPN1CES2 | |
| SCHEMBL28690606 | 0.86 | CETP (0.57) | CETPPRKCDPTGESPTPN1CES2 | |
| SCHEMBL5956741 | 0.85 | CETP (0.82) | CETPPRKCDPTGESPTPN1CES2 | |
| SCHEMBL5956717 | 0.85 | PRKCD (0.81) | CETPPRKCDPTGESPTPN1CES2 | |
| SCHEMBL6741278 | 0.85 | PRKCD (0.81) | CETPPRKCDPTGESPTPN1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090081119-A1 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-03-26 | — | — | US | claimed |
| WO-2007001684-A9 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIV PITTSBURGH (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007001684-A2 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-01-04 | — | — | WO | claimed |
| US-20100048682-A1 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2010-02-25 | — | — | US | disclosed |
| US-20090081119-A1 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-03-26 | — | — | US | disclosed |
| WO-2007001684-A9 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIV PITTSBURGH (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007001684-A2 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-01-04 | — | — | WO | disclosed |