Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1772738 | 0.77 | SMN1; SMN2 (0.49) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL1772736 | 0.77 | MAP3K5 (0.42) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10729866 | 0.75 | MAP3K5 (0.39) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL10729096 | 0.74 | MAP3K5 (0.46) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL3335727 | 0.73 | MAP3K5 (0.39) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL13424029 | 0.73 | MAP3K5 (0.51) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL2929504 | 0.73 | MAP3K5 (0.42) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL10728994 | 0.73 | MAP3K5 (0.39) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL10733216 | 0.73 | ADORA2A (0.48) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 | |
| SCHEMBL11276468 | 0.73 | MAP3K5 (0.39) | MAP3K5SMN1; SMN2PBRM1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-02-04 | — | — | US | disclosed |
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2010-02-04 | — | — | US | disclosed |
| EP-2058309-A1 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029619-A1 | FUSED HETEROCYCLIC COMPOUND | IRAK1, IL1R1, IRAK2 | MAP3K5 42/4885SMN1; SMN2 3790/4885PBRM1 1649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.