Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.86 |
| ▸ | MAPT | P10636 | 3/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | TSHR | P16473 | 2/20 | 0.86 |
| ▸ | BLM | P54132 | 2/20 | 0.86 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.86 |
| ▸ | MEN1 | O00255 | 2/20 | 0.86 |
| ▸ | MPO | P05164 | 1/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL27136920 | 1.00 | KMT2A (0.86) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL1289777 | 1.00 | KMT2A (0.86) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL3487478 | 1.00 | KMT2A (0.86) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL4287329 | 0.96 | KDM4E (0.80) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL4296800 | 0.95 | KMT2A (0.78) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL23141133 | 0.93 | KMT2A (1.00) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL475350 | 0.93 | KMT2A (1.00) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL475349 | 0.93 | KMT2A (1.00) | KMT2AKDM4EMAPTLMNATSHR | |
| Dl-Tryptophan SCHEMBL19161120 | 0.93 | KMT2A (1.00) | KMT2AKDM4EMAPTLMNATSHR | |
| Tryptophan SCHEMBL4732053 | 0.93 | KMT2A (1.00) | KMT2AKDM4EMAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024069007-A2 | IMMUNOSUPPRESSIVE COMPOUNDS | UNIVERSITÄT BASEL (CH) | 2024-04-04 | — | — | WO | disclosed |
| EP-1998795-B1 | CORONIN 1 MODULATORS FOR THE TREATMENT OF AUTOIMMUNE AND LYMPHOPROLIFERATIVE DISORDERS AND MYCOBACTERIAL INFECTIONS | UNIV BASEL (CH) | 2015-12-02 | — | — | EP | disclosed |
| US-8728438-B2 | Coronin 1 modulators for the treatment of autoimmune and lymphoproliferative disorders and mycobacterial infections | UNIVERSITY OF BASEL (CH) | 2014-05-20 | — | — | US | disclosed |
| US-20130336966-A1 | CORONIN 1 MODULATORS FOR THE TREATMENT OF AUTOIMMUNE AND LYMPHOPROLIFERATIVE DISORDERS AND MYCOBACTERIAL INFECTIONS | UNIVERSITY OF BASEL (CH) | 2013-12-19 | — | — | US | disclosed |
| US-8518372-B2 | Coronin 1 modulators for the treatment of autoimmune and Lymphoproliferative disorders and mycobacterial infections | UNIVERSITY OF BASEL (CH) | 2013-08-27 | — | — | US | disclosed |
| US-20100008931-A1 | Coronin 1 Modulators for the Treatment of Autoimmune and Lymphoproliferative Disorders and Mycobacterial Infections | UNIVERSITY OF BASEL | 2010-01-14 | — | — | US | disclosed |
| EP-1998795-A2 | CORONIN 1 MODULATORS FOR THE TREATMENT OF AUTOIMMUNE AND LYMPHOPROLIFERATIVE DISORDERS AND MYCOBACTERIAL INFECTIONS | University of Basel (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007110385-A2 | CORONIN 1 MODULATORS FOR THE TREATMENT OF AUTOIMMUNE AND LYMPHOPROLIFERATIVE DISORDERS AND MYCOBACTERIAL INFECTIONS | UNIVERSITY OF BASEL (CH) | 2007-10-04 | — | — | WO | disclosed |