⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3090384 | 0.77 | — | — | |
| SCHEMBL1006106 | 0.75 | — | — | |
| SCHEMBL29773154 | 0.75 | — | — | |
| SCHEMBL151617 | 0.75 | — | — | |
| SCHEMBL4617828 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL30837147 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL27927282 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL28316705 | 0.73 | HSP90AA1 (0.41) | — | |
| SCHEMBL23704165 | 0.71 | — | — | |
| SCHEMBL29994024 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279888-A | Polypeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2021-01-29 | — | — | CN | claimed |
| CN-112209991-A | Tripeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2021-01-12 | — | — | CN | claimed |
| US-20180334440-A1 | INHIBITORS OF ARGININE GINGIPAIN | Cortexyme, Inc. (US) | 2018-11-22 | — | — | US | claimed |
| CN-108779085-A | In pharmacophore, the Compounds and methods for by inhibiting that there is application in CYP17A1 and CYP19A1 treating cancers | 马古苏托科技大学 | 2018-11-09 | — | — | CN | claimed |
| CN-108602787-A | The inhibitor of arginine porphyromonas mycoproteinase | 库特克希米公司 | 2018-09-28 | — | — | CN | claimed |
| EP-3374352-A1 | INHIBITORS OF ARGININE GINGIPAIN | Cortexyme, Inc. (US) | 2018-09-19 | — | — | EP | claimed |
| CN-107428762-A | Phthalazinone derivatives, preparation method and the usage | 四川科伦博泰生物医药股份有限公司 | 2017-12-01 | — | — | CN | claimed |
| WO-2017201322-A1 | TREATMENT OF OSTEOARTHRITIS WITH GINGIPAIN BLOCKING AGENTS | Cortexyme, Inc. (US) | 2017-11-23 | — | — | WO | claimed |
| EP-3204352-A2 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2017-08-16 | — | — | EP | claimed |
| CN-106749259-A | A kind of synthetic method of cyclopenta pyrimido azoles | 华东师范大学 | 2017-05-31 | — | — | CN | claimed |
| WO-2015057992-A1 | BTK INHIBITORS FOR HEMATOPOIETIC MOBILIZATION | IZUMI RAQUEL (US) | 2015-04-23 | — | — | WO | claimed |
| CN-104395302-A | 1- [ m-carboxamido (hetero) aryl-methyl ] -heterocyclyl-carboxamide derivatives | ACTELION PHARMACEUTICALS LTD | 2015-03-04 | — | — | CN | claimed |
| US-8211933-B2 | 3.3.0 bicyclic GlyT1 inhibitors and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2012-07-03 | — | — | US | claimed |
| CN-101845091-A | Metastin derivative and use thereof | TAKEDA PHARMACEUTICAL | 2010-09-29 | — | — | CN | claimed |
| CN-100371329-C | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases | AVENTIS PHARMA GMBH (DE) | 2008-02-27 | — | — | CN | claimed |
| EP-1620381-A1 | HYDROANTHRACENE BASED COMPOUNDS AS ANTICANCER AGENTS | Dabur Research Foundation (IN) | 2006-02-01 | — | — | EP | claimed |
| CN-1714083-A | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases | AVENTIS PHARMA GMBH (DE) | 2005-12-28 | — | — | CN | claimed |
| US-6949557-B2 | Hydroanthracene based compounds as anticancer agents | DABUR RESEARCH FOUNDATION (IN) | 2005-09-27 | — | — | US | claimed |
| WO-2004096742-A1 | HYDROANTHRACENE BASED COMPOUNDS AS ANTICANCER AGENTS | DABUR RESEARCH FOUNDATION (IN) | 2004-11-11 | — | — | WO | claimed |
| US-20040220197-A1 | Hydroanthracene based compounds as anticancer agents | DABUR RESEARCH FOUNDATION | 2004-11-04 | — | — | US | claimed |