Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zuclomiphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 11/20 | 1.00 |
| ▸ | EBP | Q15125 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 3/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | HTR6 | P50406 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enclomiphene SCHEMBL5083138 | 1.00 | ESR1 (1.00) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| Enclomiphene SCHEMBL34893 | 1.00 | ESR1 (1.00) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| Enclomiphene SCHEMBL20594021 | 1.00 | ESR1 (1.00) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| Clomiphene SCHEMBL29379763 | 1.00 | ESR1 (1.00) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| SCHEMBL10407739 | 1.00 | ESR1 (1.00) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| Enclomiphene SCHEMBL407458 | 0.99 | ESR1 (0.97) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| Clomiphene SCHEMBL27689011 | 0.99 | ESR1 (0.97) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| Zuclomiphene SCHEMBL402392 | 0.99 | ESR1 (0.97) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| Zuclomiphene SCHEMBL23357662 | 0.95 | ESR1 (0.90) | ESR1EBPKMT2ASIGMAR1CYP2D6 | |
| 4-Oh-Enclomiphene SCHEMBL17152123 | 0.95 | ESR1 (0.90) | ESR1EBPKMT2ASIGMAR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9898 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116850183-B | Methods and pharmaceutical compositions for treating myopia | GRAND PHARMA (CHINA) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122005600-A | Application of AMPD3 gene expression inhibitor in preparation of medicines for preventing and treating polycystic ovary syndrome | 武汉大学中南医院 | 2026-05-12 | — | — | CN | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| US-12569624-B2 | Devices, methods and compositions for reproductive organs | FEMASYS INC. (US) | 2026-03-10 | — | — | US | claimed |
| US-12550885-B2 | Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells | UNIVERSITY OF CINCINNATI (US) | 2026-02-17 | — | — | US | claimed |
| US-20260042834-A1 | ANTI-CORTICOTROPIN-RELEASING HORMONE ANTIBODIES AND POLYCYSTIC OVARY SYNDROME | HBM ALPHA THERAPEUTICS INC (US) | 2026-02-12 | — | — | US | claimed |
| EP-4690242-A1 | SYSTEM AND METHOD FOR CREATING A QUANTIFIABLE IVF PHENOTYPE MAP TO DRIVE DISCOVERY OF IVF PROGNOSTICS | Univfy, Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| EP-4658278-A1 | SELECTIVE FIASMA TREATMENT | Valo Health, Inc. (US) | 2025-12-10 | — | — | EP | claimed |
| US-20250332222-A1 | BATCH MANAGEMENT METHOD FOR IMPROVING FARROWING RATE OR NUMBER OF PIGLETS BORN ALIVE IN SWINE | UNIV CHINA AGRICULTURAL (CN) | 2025-10-30 | — | — | US | claimed |
| EP-0305497-A1 | FERTILITY PREDICTION BY USE OF CLOMIPHENE CHALLENGE TEST. | NAVOT DANIEL | 1989-03-08 | — | — | EP | claimed |
| WO-1988008273-A1 | PHOTOCHARACTERIZATION AND TREATMENT OF NORMAL, ABNORMAL AND ECTOPIC ENDOMETRIUM | VANCAILLIE THIERRY GEORGES (US) | 1988-11-03 | — | — | WO | claimed |
| WO-1988006863-A1 | FERTILITY PREDICTION BY USE OF CLOMIPHENE CHALLENGE TEST | NAVOT DANIEL (US) | 1988-09-22 | — | — | WO | claimed |
| US-4729999-A | MENOPAUSE, SIDE EFFECT PREVENTION | BCM TECHNOLOGIES (US) | 1988-03-08 | — | — | US | claimed |
| EP-0178862-A2 | Antiestrogen therapy for symptoms of estrogen deficiency | BCM Technologies, INC. (US) | 1986-04-23 | — | — | EP | claimed |
| EP-0085706-A4 | METHOD OF INCREASING THE INCIDENCE OF FEMALE OFFSPRING. | GAMETRICS LTD (US) | 1983-12-23 | — | — | EP | claimed |
| EP-0085706-A1 | METHOD OF INCREASING THE INCIDENCE OF FEMALE OFFSPRING | GAMETRICS LIMITED (US) | 1983-08-17 | — | — | EP | claimed |
| WO-1983000629-A1 | METHOD OF INCREASING THE INCIDENCE OF FEMALE OFFSPRING | GAMETRICS LTD (US) | 1983-03-03 | — | — | WO | claimed |
| US-4339434-A | Method of increasing the incidence of female offspring | GAMETRICS LIMITED (US) | 1982-07-13 | — | — | US | claimed |
| US-4061733-A | Veterinary compositions for inducing estrus in animals and method | GUNJIKAR NARAYAN VISHWANATH | 1977-12-06 | — | — | US | claimed |