Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.46 |
| ▸ | CPN1 | P15169 | 4/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | GLI1 | P08151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 3/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL28870346 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL27998796 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL4398351 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL28149498 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL3103208 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL1675268 | 1.00 | PTGS1 (0.46) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL5144381 | 0.95 | PTGS1 (0.41) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL1298202 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL15049946 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 | |
| Proline SCHEMBL15050063 | 0.94 | PTGS1 (0.52) | PTGS1SLC7A11CPN1CPB2NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152882-A2 | CELLS EXPRESSING CHIMERIC PROTEINS AND ASSAYS USING SUCH CELLS | Achillion Pharmaceuticals, Inc. (US) | 2010-02-17 | — | — | EP | claimed |
| WO-2008134640-A2 | CELLS EXPRESSING CHIMERIC NS4A PROTEINS OF HCV AND THEIR USE IN ASSAYS | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | claimed |
| US-20100093018-A1 | CELLS EXPRESSING CHIMERIC PROTEINS AND ASSAYS USING SUCH CELLS | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | US | disclosed |