Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.68 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.57 |
| ▸ | CTSD | P07339 | 4/20 | 0.51 |
| ▸ | CTSB | P07858 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3490661 | 1.00 | BACE1 (0.68) | BACE1BACE2CTSDCTSBBCHE | |
| SCHEMBL3489105 | 0.84 | BACE1 (0.70) | BACE1BACE2CTSDCTSB | |
| SCHEMBL3357005 | 0.83 | BACE1 (0.68) | BACE1BACE2CTSDCTSBBCHE | |
| SCHEMBL3356997 | 0.83 | BACE1 (0.68) | BACE1BACE2CTSDCTSBBCHE | |
| SCHEMBL3491516 | 0.83 | BACE1 (0.57) | BACE1BACE2CTSDCTSB | |
| SCHEMBL3491517 | 0.83 | BACE1 (0.57) | BACE1BACE2CTSDCTSB | |
| SCHEMBL3349028 | 0.82 | BACE1 (0.56) | BACE1BACE2CTSDCTSB | |
| SCHEMBL3349045 | 0.82 | BACE1 (0.56) | BACE1BACE2CTSDCTSB | |
| SCHEMBL4392171 | 0.81 | BACE1 (0.54) | BACE1BACE2CTSDCTSB | |
| SCHEMBL4392167 | 0.81 | BACE1 (0.54) | BACE1BACE2CTSDCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048590-A1 | N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS | GAILUNAS ANDREA | 2010-02-25 | — | — | US | claimed |
| EP-1409450-B1 | N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS | ELAN PHARM INC (US) | 2009-12-09 | — | — | EP | claimed |
| US-20060194817-A1 | N- (3-amino-2-hydroxy-propyl) substituted alkylamide compounds | ELAN PHARMACEUTICALS, INC. | 2006-08-31 | — | — | US | claimed |
| US-20030109559-A1 | N-(3-amino-2-hydroxy-propyl)substituted alkylamide compounds | PHARMACIA & UPJOHN COMPANY | 2003-06-12 | — | — | US | claimed |
| EP-1409450-B1 | N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS | ELAN PHARM INC (US) | 2009-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109559-A1 | N-(3-amino-2-hydroxy-propyl)substituted alkylamide compounds | BACE1, APP, BACE2 | BACE1 1/4885BACE2 3/4885CTSD 231/4885 |
| US-20060194817-A1 | N- (3-amino-2-hydroxy-propyl) substituted alkylamide compounds | BACE1, APP, BACE2 | BACE1 1/4885BACE2 3/4885CTSD 282/4885 |
| US-20100048590-A1 | N-(3-AMINO-2-HYDROXY-PROPYL) SUBSTITUTED ALKYLAMIDE COMPOUNDS | BACE1, APP, BACE2 | BACE1 1/4885BACE2 3/4885CTSD 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.