Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200620 | 0.77 | CMA1 (0.51) | CMA1BRD9ALDH1A1MAPTPOLB | |
| SCHEMBL2248371 | 0.75 | MAPT (0.46) | CMA1BRD9ALDH1A1MAPTPOLB | |
| SCHEMBL5271800 | 0.75 | MAPT (0.46) | CMA1BRD9ALDH1A1MAPTPOLB | |
| SCHEMBL5237697 | 0.72 | NOTUM (0.50) | ALDH1A1MAPTNOTUM | |
| SCHEMBL24434520 | 0.71 | CMA1 (0.56) | CMA1ALDH1A1MAPTPOLBHSD17B10 | |
| SCHEMBL13727501 | 0.70 | NPC1 (0.59) | CMA1BRD9ALDH1A1MAPTHSD17B10 | |
| SCHEMBL11696465 | 0.70 | CMA1 (0.55) | CMA1ALDH1A1MAPTPOLBHSD17B10 | |
| SCHEMBL11129636 | 0.70 | CMA1 (0.51) | CMA1BRD9ALDH1A1MAPTPOLB | |
| SCHEMBL19500868 | 0.68 | MAPT (0.59) | CMA1ALDH1A1MAPTPOLBHSD17B10 | |
| SCHEMBL17304816 | 0.68 | CMA1 (0.49) | CMA1BRD9ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093716-A1 | THERAPEUTIC METHODS USING WRN BINDING MOLECULES | TRUSTEES OF BOSTON UNIVERSITY AND PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-04-15 | — | — | US | disclosed |
| EP-2061797-A1 | THERAPEUTIC METHODS USING WRN BINDING MOLECULES | TRUSTEES OF BOSTON UNIVERSITY (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008027990-A1 | THERAPEUTIC METHODS USING WRN BINDING MOLECULES | TRUSTEES OF BOSTON UNIVERSITY (US) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093716-A1 | THERAPEUTIC METHODS USING WRN BINDING MOLECULES | WRN, BLM, RECQL | CMA1 4334/4885BRD9 2040/4885ALDH1A1 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.