Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.55 |
| ▸ | CDK1 | P06493 | 3/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.55 |
| ▸ | CDK9 | P50750 | 2/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.49 |
| ▸ | STK4 | Q13043 | 7/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3496417 | 0.89 | SYK (0.53) | CDK2CCNE1CCNB2CDK1CCNB1 | |
| SCHEMBL3495796 | 0.89 | CDK2 (0.58) | CDK2CCNE1CCNB2CDK1CCNB1 | |
| SCHEMBL3494931 | 0.87 | PRKCQ (0.54) | CDK2CCNE1CCNB2CDK1CCNB1 | |
| SCHEMBL3497350 | 0.85 | AURKA (0.58) | PRKCQSYKAURKAAURKB | |
| SCHEMBL3493781 | 0.85 | PRKCQ (0.56) | CDK2CDK1CDK5PRKCQSYK | |
| SCHEMBL3496536 | 0.84 | AURKA (0.58) | PRKCQSYKAURKAAURKB | |
| SCHEMBL3495899 | 0.83 | PRKCQ (0.59) | CDK2CCNE1CDK1CDK5CCNT1 | |
| SCHEMBL3495520 | 0.82 | PRKCQ (0.56) | CDK2CCNE1CDK1CDK5CCNT1 | |
| SCHEMBL3497975 | 0.82 | SYK (0.61) | PRKCQSYKAURKA | |
| SCHEMBL3493976 | 0.82 | PRKCQ (0.54) | CDK2CDK1CDK5PRKCQSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. | 2010-05-27 | — | — | US | claimed |
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | PRKCH, PKD2, PRKCQ | CDK2 129/4885CCNE1 1873/4885CCNB2 1693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.