Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 2/20 | 0.57 |
| ▸ | MERTK | Q12866 | 4/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | CTSC | P53634 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 8/20 | 0.38 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3496186 | 0.93 | PRKCQ (0.53) | PRKCQMERTKTYRO3AXLCTSC | |
| SCHEMBL3495649 | 0.92 | PRKCQ (0.67) | PRKCQMERTKTYRO3AXLEGFR | |
| SCHEMBL3496448 | 0.89 | PRKCQ (0.50) | PRKCQMERTKTYRO3AXLCTSC | |
| SCHEMBL1742512 | 0.89 | PRKCQ (0.56) | PRKCQMERTKTYRO3AXLCTSC | |
| SCHEMBL3495463 | 0.89 | PRKCQ (0.52) | PRKCQMERTKTYRO3AXLCTSC | |
| SCHEMBL3495941 | 0.88 | PRKCQ (0.53) | PRKCQMERTKTYRO3AXLCTSC | |
| SCHEMBL3493194 | 0.87 | PRKCQ (0.61) | PRKCQAXLEGFRBTKKDR | |
| SCHEMBL3495009 | 0.87 | PRKCQ (0.61) | PRKCQMERTKTYRO3AXLEGFR | |
| SCHEMBL3493962 | 0.87 | PRKCQ (0.55) | PRKCQULK1ULK2 | |
| SCHEMBL1739930 | 0.87 | PRKCQ (0.60) | PRKCQMERTKTYRO3AXLCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. | 2010-05-27 | — | — | US | claimed |
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | RIGEL PHARMACEUTICALS, INC. | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130486-A1 | CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS | PRKCH, PKD2, PRKCQ | PRKCQ 3/4885MERTK 573/4885TYRO3 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.