Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UNG | P13051 | 5/20 | 0.90 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | XBP1 | P17861 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506784 | 0.94 | UNG (1.00) | UNGGPR84 | |
| SCHEMBL7962222 | 0.94 | UNG (1.00) | UNGGPR84 | |
| SCHEMBL7950536 | 0.94 | UNG (1.00) | UNGGPR84 | |
| SCHEMBL7951357 | 0.79 | UNG (1.00) | UNGGPR84 | |
| SCHEMBL7962219 | 0.79 | UNG (1.00) | UNGGPR84 | |
| SCHEMBL3971657 | 0.77 | UNG (0.60) | UNGTP53 | |
| SCHEMBL5298937 | 0.77 | TP53 (0.71) | TP53MAPTHTTSMN1; SMN2 | |
| SCHEMBL7951382 | 0.76 | UNG (0.58) | UNGTP53 | |
| SCHEMBL7951381 | 0.76 | UNG (0.58) | UNGTP53 | |
| SCHEMBL7967579 | 0.75 | UNG (0.58) | UNGTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143332-A1 | COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION | 2010-06-10 | — | — | US | claimed |
| EP-2086644-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2009-08-12 | — | — | EP | claimed |
| WO-2008063558-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2008-05-29 | — | — | WO | claimed |
| US-20100143332-A1 | COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| EP-2086644-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008063558-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |
| US-4576948-A | Composition and method for inhibiting terminal deoxyribonucleotidyl transferase activity | TRUSTEES BOSTON UNIVERSITY (US) | 1986-03-18 | — | — | US | disclosed |
| WO-1982004192-A1 | COMPOSITION AND METHOD FOR INHIBITING TERMINAL DEOXYRIBONUCLEOTIDYL TRANSFERASE ACTIVITY | MCCAFFREY RONALD | 1982-12-09 | — | — | WO | disclosed |