Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.90 |
| ▸ | GRM8 | O00222 | 2/20 | 0.90 |
| ▸ | GRM6 | O15303 | 2/20 | 0.90 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.90 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.90 |
| ▸ | GSR | P00390 | 2/20 | 0.90 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.90 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.90 |
| ▸ | GRM5 | P41594 | 1/20 | 0.90 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.90 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.90 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.90 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.90 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.90 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.90 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.90 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.90 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL4950900 | 0.97 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL4950904 | 0.97 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL16569602 | 0.97 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL518392 | 0.97 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL218575 | 0.97 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL4025168 | 0.95 | GRM8 (0.90) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL11697698 | 0.95 | GRM8 (0.90) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL11431055 | 0.95 | GRM8 (0.90) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL10427278 | 0.95 | GRM8 (0.90) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL10824536 | 0.95 | GRM8 (0.90) | GRM8GRM6GRM7GRM4GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0108937-A2 | Process for the production of amino-dicarboxylic acid-bivalent metal-halogen complexes and novel such complexes | Verla-Pharm Arzneimittelfabrik Apotheker H.J. von Ehrlich GmbH & Co. KG (DE) | 1984-05-23 | — | — | EP | claimed |
| US-12472203-B2 | Composition and method for treating hearing loss | Soundbites Public Benefit Corporation (US) | 2025-11-18 | — | — | US | disclosed |
| US-20250268933-A1 | COMPOSITION AND METHOD FOR TREATING HEARING LOSS | Soundbites Public Benefit Corporation | 2025-08-28 | — | — | US | disclosed |
| US-12329775-B2 | Composition and method for treating hearing loss | Soundbites Public Benefit Corporation (US) | 2025-06-17 | — | — | US | disclosed |
| US-20250057875-A1 | COMPOSITION AND METHOD FOR TREATING HEARING LOSS | Soundbites Public Benefit Corporation | 2025-02-20 | — | — | US | disclosed |
| WO-2025038498-A2 | COMPOSITION AND METHOD FOR TREATING HEARING LOSS | Soundbites Public Benefit Corporation (US) | 2025-02-20 | — | — | WO | disclosed |
| US-20160369237-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECH INC (US) | 2016-12-22 | — | — | US | disclosed |
| US-20100184033-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | Lineage Cell Therapeutics, Inc. | 2010-07-22 | — | — | US | disclosed |
| US-20080226601-A1 | Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods | UNIVERSITY OF ROCHESTER (US) | 2008-09-18 | — | — | US | disclosed |
| EP-1903873-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | THE UNIVERSITY OF ROCHESTER (US) | 2008-04-02 | — | — | EP | disclosed |
| US-20080070303-A1 | Using myocardial and/or muscle progenitor cells as modeling tool in tissue engineering; regenerative medicine and organ replacement | ADVANCED CELL TECHNOLOGY | 2008-03-20 | — | — | US | disclosed |
| WO-2007062198-A1 | METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY | ADVANCED CELL TECHNOLOGY, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2006135602-A2 | HERPES VIRUS-BASED COMPOSITIONS AND METHODS OF USE IN THE PRENATAL AND PERINATAL PERIODS | UNIVERSITY OF ROCHESTER (US) | 2006-12-21 | — | — | WO | disclosed |
| EP-0108937-B1 | PROCESS FOR THE PRODUCTION OF AMINO-DICARBOXYLIC ACID-BIVALENT METAL-HALOGEN COMPLEXES AND NOVEL SUCH COMPLEXES | Verla-Pharm Arzneimittelfabrik Apotheker H.J. von Ehrlich GmbH & Co. KG (DE) | 1989-01-25 | — | — | EP | disclosed |
| US-4546195-A | Process for the production of amino-dicarboxylic acid-bivalent metal-halogen complexes and such complexes | VERLA-PHARM, ARZNEIMITTELFABRIK, APOTHEKER H.J.V. EHRLICH GMBH & CO. KG (DE) | 1985-10-08 | — | — | US | disclosed |
| EP-0108937-A2 | Process for the production of amino-dicarboxylic acid-bivalent metal-halogen complexes and novel such complexes | Verla-Pharm Arzneimittelfabrik Apotheker H.J. von Ehrlich GmbH & Co. KG (DE) | 1984-05-23 | — | — | EP | disclosed |
| US-4041154-A | Magnesium-containing pharmaceutical compositions | VERLA-PHARM ARZNEIMITTEL-FABRIK APOTHEKER H. J. V. EHRLICH (DT) | 1977-08-09 | — | — | US | disclosed |