Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511585 | 0.90 | JAK2 (0.56) | JAK2KCNH2JAK3 | |
| SCHEMBL3675028 | 0.86 | JAK2 (0.51) | JAK2KCNH2JAK3 | |
| SCHEMBL3675279 | 0.84 | JAK2 (0.43) | JAK2KCNH2JAK3 | |
| SCHEMBL3672008 | 0.83 | JAK2 (0.41) | JAK2KCNH2JAK3 | |
| SCHEMBL3671676 | 0.82 | JAK2 (0.52) | JAK2KCNH2JAK3 | |
| SCHEMBL13270335 | 0.81 | JAK2 (0.40) | JAK2KCNH2JAK3 | |
| SCHEMBL3676013 | 0.81 | JAK2 (0.44) | JAK2KCNH2JAK3 | |
| SCHEMBL3670396 | 0.80 | JAK2 (0.50) | JAK2KCNH2JAK3 | |
| SCHEMBL3674595 | 0.80 | JAK2 (0.42) | JAK2KCNH2JAK3 | |
| SCHEMBL3678337 | 0.79 | JAK2 (0.64) | JAK2KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367706-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20100256097-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256097-A1 | INHIBITORS OF JANUS KINASES | JAK2, JAK3, JAK1 | JAK2 1/4885KCNH2 1655/4885JAK3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.