Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.66 |
| ▸ | CNR1 | P21554 | 3/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.49 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24937532 | 0.91 | CNR2 (0.80) | CNR2CNR1HIF1AMAPT | |
| SCHEMBL3512731 | 0.85 | EGLN1 (0.65) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL3513909 | 0.85 | CNR2 (0.58) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL3512393 | 0.85 | CNR2 (0.58) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL3514102 | 0.83 | CNR2 (0.56) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL3516806 | 0.83 | CNR2 (0.56) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL3513720 | 0.82 | CNR2 (0.57) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL3512643 | 0.81 | CNR2 (0.54) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL4566579 | 0.81 | CNR2 (0.54) | CNR2CNR1PTGDR2EGLN1EGLN2 | |
| SCHEMBL3512358 | 0.81 | CNR2 (0.54) | CNR2CNR1PTGDR2EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | claimed |
| CN-101663037-A | Novel 1,8-naphthyridine compounds | MERCK & CO INC | 2010-03-03 | — | — | CN | claimed |
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-03-04 | — | — | US | disclosed |
| CN-101663037-A | Novel 1,8-naphthyridine compounds | MERCK & CO INC | 2010-03-03 | — | — | CN | disclosed |
| WO-2008130527-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | MERCK & CO., INC. (US) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056563-A1 | NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS | HIF1AN, HIF1A, EGLN2 | CNR2 2485/4885CNR1 1567/4885PTGDR2 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.