Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.68 |
| ▸ | SMPD3 | Q9NY59 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | NEK2 | P51955 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513251 | 0.85 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3513578 | 0.83 | SMPD3 (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGSMPD3 | |
| SCHEMBL3513764 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3514275 | 0.81 | SMPD3 (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGSMPD3 | |
| SCHEMBL3512900 | 0.80 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3CBPIK3CGSMPD3 | |
| SCHEMBL3513424 | 0.80 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGSMPD3 | |
| SCHEMBL532711 | 0.80 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGPDE4B | |
| SCHEMBL532710 | 0.80 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGPDE4B | |
| SCHEMBL12988800 | 0.79 | PIK3CA (0.85) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3517108 | 0.79 | PIK3CD (0.85) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | CAPRARO HANS-GEORG | 2010-12-02 | — | — | US | disclosed |
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | CAPRARO HANS-GEORG | 2010-12-02 | — | — | US | disclosed |
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | CAPRARO HANS-GEORG | 2010-12-02 | — | — | US | disclosed |
| WO-2008138834-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305113-A1 | Substituted Imidazopyridazines as Lipid Kinase Inhibitors | PI4KA, PIK3CA, PIK3CB | PIK3CA 2/4885PIK3CD 4/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.