⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351014 | 0.97 | — | — | |
| SCHEMBL4487623 | 0.93 | — | — | |
| SCHEMBL352623 | 0.93 | — | — | |
| SCHEMBL2223430 | 0.90 | — | — | |
| SCHEMBL2049131 | 0.86 | — | — | |
| SCHEMBL13280431 | 0.79 | — | — | |
| SCHEMBL334983 | 0.77 | — | — | |
| SCHEMBL3707605 | 0.73 | CXCR4 (0.30) | — | |
| SCHEMBL2224647 | 0.72 | — | — | |
| SCHEMBL3066622 | 0.69 | APOBEC3A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3972589-B1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | claimed |
| US-12012410-B2 | Substituted pyrazolo[1,5-a]pyrazines for spinal muscular atrophy | REBORNA BIOSCIENCES, INC. (JP) | 2024-06-18 | — | — | US | claimed |
| WO-2024094156-A1 | AMINE COMPOUND AND USE THEREOF | 石药集团中奇制药技术（石家庄）有限公司 | 2024-05-10 | — | — | WO | claimed |
| EP-4320125-A1 | PYRIDINYL SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2024-02-14 | — | — | EP | claimed |
| WO-2023247590-A1 | TRIAZOLOPYRIDINE AND BENZOISOXAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |
| US-20230373960-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEONE MEDICINES I GMBH (CH) | 2023-11-23 | — | — | US | claimed |
| US-20220287748-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR SPINAL MUSCULAR ATROPHY | REBORNA BIOSCIENCES, INC. (JP) | 2022-09-15 | — | — | US | claimed |
| US-20220281886-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | MERCK SHARP DOHME CORP. (US) | 2022-09-08 | — | — | US | claimed |
| EP-3972589-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | Merck Sharp & Dohme Corp. (US) | 2022-03-30 | — | — | EP | claimed |
| WO-2022006456-A1 | TRICYCLIC PYRIDONE COMPOUNDS AS JAK2 V617F INHIBITORS | INCYTE CORPORATION (US) | 2022-01-06 | — | — | WO | claimed |
| WO-2010147792-A2 | COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-23 | — | — | WO | claimed |
| US-20090275619-A1 | Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-11-05 | — | — | US | claimed |
| WO-2009105509-A1 | AMINE AND ETHER COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-27 | — | — | WO | claimed |
| EP-2007733-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-12-31 | — | — | EP | claimed |
| WO-2007113596-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-10-11 | — | — | WO | claimed |
| US-4921947-A | Process for preparing macrolide derivatives | ELI LILLY AND COMPANY (US) | 1990-05-01 | — | — | US | claimed |
| US-4820695-A | GRAMNEGATIVE BACTERIA | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | claimed |
| EP-0103465-B1 | 20-AMINO MACROLIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1986-09-10 | — | — | EP | claimed |
| US-4604380-A | ADMINISTERING TO TREAT BACTERIAL OR MYCOPLASMAL INFECTION | ELI LILLY AND COMPANY (US) | 1986-08-05 | — | — | US | claimed |
| EP-0103465-A1 | 20-Amino macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-03-21 | — | — | EP | claimed |