Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 11/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3515795 | 0.85 | TNF (0.50) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3512871 | 0.85 | TNF (0.68) | TNFPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12986576 | 0.84 | TNF (0.57) | TNFPIK3CADYRK1AJAK2RET | |
| SCHEMBL3514693 | 0.78 | TNF (0.52) | TNFPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3515087 | 0.73 | TNF (0.69) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3515357 | 0.71 | TNF (0.65) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3516841 | 0.69 | TNF (0.63) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL12985683 | 0.69 | TNF (0.63) | TNFPIK3CADYRK1APIK3CDPIK3CB | |
| SCHEMBL3512759 | 0.69 | FYN (0.65) | TNF | |
| SCHEMBL3514237 | 0.68 | TNF (0.62) | TNFPIK3CADYRK1APIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311729-A1 | Substituted imidazopyridazines and pyrrolopyrimidines as lipid kinase inhibitors | CAPRARO HANS-GEORG | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311729-A1 | Substituted imidazopyridazines and pyrrolopyrimidines as lipid kinase inhibitors | PI4KA, PIP5K1B, PIP4K2A | TNF 1981/4885PIK3CA 10/4885DYRK1A 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.