Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM6B | O15054 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3520489 | 0.89 | EGLN3 (0.52) | EGLN3ABL1FTOEGLN1KDM5B | |
| SCHEMBL3518292 | 0.87 | EGLN3 (0.49) | EGLN3ABL1FTOEGLN1KDM5B | |
| SCHEMBL3757200 | 0.85 | EGLN3 (0.57) | EGLN3FTOEGLN1KDM5BKDM2A | |
| SCHEMBL3518484 | 0.83 | EGLN3 (0.47) | EGLN3FTOEGLN1KDM5BKDM2A | |
| SCHEMBL3523500 | 0.83 | EGLN3 (0.48) | EGLN3ABL1FTOEGLN1KDM5B | |
| SCHEMBL3519422 | 0.82 | EGLN3 (0.53) | EGLN3ABL1FTOEGLN1KDM5B | |
| SCHEMBL3518710 | 0.82 | EGLN3 (0.54) | EGLN3FTOEGLN1KDM5BKDM2A | |
| SCHEMBL3521806 | 0.82 | EGLN3 (0.52) | EGLN3ABL1FTOEGLN1KDM5B | |
| SCHEMBL3522327 | 0.82 | EGLN3 (0.52) | EGLN3ABL1FTOEGLN1KDM5B | |
| SCHEMBL3520319 | 0.81 | EGLN3 (0.55) | EGLN3FTOEGLN1KDM5BKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227770-A2 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073497-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | claimed |