Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 11/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.48 |
| ▸ | EGFR | P00533 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517589 | 1.00 | HDAC3 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13903536 | 0.94 | ENPP1 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3517486 | 0.89 | HDAC3 (0.52) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4329011 | 0.87 | ENPP1 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL641754 | 0.87 | ENPP1 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL641725 | 0.86 | ENPP1 (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4337599 | 0.86 | ENPP1 (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12518967 | 0.83 | ENPP1 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3515899 | 0.83 | IP6K1 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3516603 | 0.83 | IP6K1 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194787-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | Curis, Inc. (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009036055-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| US-20090076044-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076044-A1 | VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | KDR, HDAC1, FLT4 | HDAC3 14/4885HDAC4 9/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.