Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 0.44 |
| ▸ | CDK4 | P11802 | 10/20 | 0.44 |
| ▸ | CCND1 | P24385 | 10/20 | 0.44 |
| ▸ | CDK2 | P24941 | 10/20 | 0.44 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.44 |
| ▸ | CASK | O14936 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | CDK14 | O94921 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAK | P20794 | 1/20 | 0.44 |
| ▸ | CDK11B | P21127 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3524094 | 0.90 | CDK1 (0.38) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL4348413 | 0.90 | CDK1 (0.44) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL2397064 | 0.88 | CDK1 (0.58) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL3522557 | 0.86 | CDK2 (0.54) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL4359136 | 0.85 | CDK1 (0.41) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL4350445 | 0.84 | CDK1 (0.50) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL5654700 | 0.84 | CDK1 (0.56) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL4350748 | 0.83 | CDK1 (0.39) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL4355422 | 0.82 | CDK2 (0.58) | CDK1CDK4CCND1CDK2MAPK7 | |
| SCHEMBL4350208 | 0.82 | CDK1 (0.47) | CDK1CDK4CCND1CDK2MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705009-B2 | 4-aminopyrimidine-5-thione derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20070117821-A1 | 4-Aminopyrimidine-5-thione derivatives | DING QINGJIE | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117821-A1 | 4-Aminopyrimidine-5-thione derivatives | CDK4, CDK1, CDK2 | CDK1 2/4885CDK4 1/4885CCND1 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.