SCHEMBL35210286

SCHEMBL35210286

C=CC(=O)Nc1cc(Nc2cc(Nc3cccc(Cl)c3F)ncn2)c(OC)cc1N(C)CCN(C)C

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 0.61
ALK Q9UM73 8/20 0.58
EML4 Q9HC35 7/20 0.58
ERBB2 P04626 1/20 0.56
INSR P06213 1/20 0.56
ROS1 P08922 1/20 0.56
FER P16591 1/20 0.56
LTK P29376 1/20 0.56
BLK P51451 1/20 0.56
PTK2 Q05397 1/20 0.56
BTK Q06187 1/20 0.56
TNK2 Q07912 1/20 0.56
ERBB4 Q15303 1/20 0.56
SLK Q9H2G2 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20548806 1.00 EGFR (0.61) EGFRALKEML4ERBB2INSR
SCHEMBL19089596 0.91 EGFR (0.66) EGFRALKEML4ERBB2INSR
SCHEMBL35210284 0.91 EGFR (0.59) EGFRALKEML4
SCHEMBL19089674 0.91 EGFR (0.59) EGFRALKEML4
SCHEMBL19089369 0.90 EGFR (0.73) EGFRALKEML4PTK2
SCHEMBL20549061 0.88 EGFR (0.48) EGFRALKEML4ERBB2INSR
SCHEMBL20548919 0.87 EGFR (0.58) EGFRALKEML4
SCHEMBL35210335 0.87 EGFR (0.58) EGFRALKEML4
SCHEMBL35210347 0.86 EGFR (0.61) EGFRALKEML4
SCHEMBL19089670 0.86 EGFR (0.61) EGFRALKEML4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3398939-B1 ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) 2026-05-06 EP claimed