Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 9/20 | 0.36 |
| ▸ | CCND3 | P30281 | 8/20 | 0.36 |
| ▸ | CCND1 | P24385 | 7/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | ACACA | Q13085 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35210956 | 0.88 | CDK4 (0.35) | CDK4CCND3CCND1CDK6CDK2 | |
| SCHEMBL35210687 | 0.81 | CDK4 (0.38) | CDK4CCND3CCND1CDK6FFAR4 | |
| SCHEMBL35210550 | 0.77 | CDK4 (0.61) | CDK4CCND3CCND1CDK6 | |
| SCHEMBL30633774 | 0.75 | FFAR4 (0.40) | CDK4CCND3CCND1CDK6CDK2 | |
| SCHEMBL35210556 | 0.74 | CCND3 (0.65) | CDK4CCND3CCND1CDK6 | |
| SCHEMBL35211024 | 0.74 | NR4A2 (0.37) | CDK4CCND3CCND1CDK6CDK2 | |
| SCHEMBL30633711 | 0.74 | EGFR (0.39) | KCNH2CDK4CCND3CCND1CDK6 | |
| SCHEMBL35211188 | 0.73 | MAP2K1 (0.39) | KDRNTRK1 | |
| SCHEMBL24632941 | 0.72 | CDK4 (0.43) | CDK4CCND3CCND1CDK6CDK2 | |
| SCHEMBL29212038 | 0.71 | BRD4 (0.42) | CDK4CDK6CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | INCYTE CORP (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125391-A1 | PYRIMIDINE INDOLES AS CDK4 INHIBITORS | CDK4, CCNA1, CCNO | KCNH2 3745/4885CDK4 1/4885CCND3 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.