Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | GLA | P06280 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35211259 | 0.83 | HSD17B3 (0.55) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL1590671 | 0.82 | HSD17B3 (0.77) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL959639 | 0.81 | HSD17B3 (0.61) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL962805 | 0.80 | HSD17B3 (0.70) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL961332 | 0.80 | HSD17B3 (0.66) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL960904 | 0.79 | HSD17B3 (0.56) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL30615264 | 0.79 | HSD17B3 (0.56) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL959893 | 0.79 | KDM4E (0.76) | HSD17B3KDM4EGLAGAAERAP1 | |
| SCHEMBL30886550 | 0.79 | MAP2K1 (0.65) | KDM4EGAAALDH1A1HPGDHSD17B10 | |
| SCHEMBL5652992 | 0.77 | HSD17B3 (0.62) | HSD17B3KDM4EGLAGAAERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125376-A1 | IRREVERSIBLE INACTIVATORS TARGETING ARAF/MEK COMPLEXES | GERO THOMAS (US) | 2026-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260125376-A1 | IRREVERSIBLE INACTIVATORS TARGETING ARAF/MEK COMPLEXES | ARAF, BRAF, RAF1 | HSD17B3 3803/4885KDM4E 2105/4885GLA 3899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.