Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 13/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | THPO | P40225 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 2/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3522158 | 0.92 | SCNN1A (0.47) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL13165421 | 0.88 | PLAU (0.52) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3522163 | 0.84 | PLAU (0.43) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3520461 | 0.83 | SCNN1A (0.53) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3521532 | 0.80 | SCNN1A (0.40) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3530139 | 0.80 | SCNN1A (0.47) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3527582 | 0.80 | SCNN1A (0.43) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL3524523 | 0.76 | SCNN1A (0.36) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL13165426 | 0.76 | PLAU (0.56) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL5014166 | 0.76 | PLAU (0.48) | SCNN1AALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803804-B2 | Substituted pyrazines for use in the treatment of inflammatory or allergic conditions | NOVARTIS AG (CH) | 2010-09-28 | — | — | US | disclosed |