Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluvoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 10/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.83 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.83 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluvoxamine SCHEMBL7339196 | 1.00 | MEN1 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL29014388 | 1.00 | MEN1 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL3863487 | 1.00 | MEN1 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL31022880 | 1.00 | MEN1 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL782847 | 1.00 | MEN1 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL31495839 | 0.93 | MEN1 (0.87) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL27816994 | 0.91 | SLC6A4 (0.95) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL5569574 | 0.91 | SLC6A4 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL341698 | 0.91 | SLC6A4 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM | |
| Fluvoxamine SCHEMBL178609 | 0.91 | SLC6A4 (1.00) | MEN1LMNAKMT2ASMN1; SMN2BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4252 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| EP-4566590-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | Harbin Kanon Pharmaceutical Co., Ltd (CN) | 2025-06-11 | — | — | EP | claimed |
| CN-119595798-A | High performance liquid chromatography for efficiently separating and detecting isomer impurities in fluvoxamine maleate | 河北医科大学 | 2025-03-11 | — | — | CN | claimed |
| CN-115998697-B | Preparation method of fluvoxamine maleate film coated tablet | 河北龙海药业有限公司 | 2025-01-28 | — | — | CN | claimed |
| US-20240295545-A1 | GLIOMA THERAPY | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2024-09-05 | — | — | US | claimed |
| CN-117462516-B | Sustained-release pellet, preparation method thereof and pellet tablet thereof | 青岛海洋生物医药研究院 | 2024-08-30 | — | — | CN | claimed |
| CN-117503707-B | Taste-masking microsphere and preparation process and application thereof | 哈尔滨市康隆药业有限责任公司 | 2024-08-23 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-118121555-A | Fluvoxamine maleate tablet and preparation method thereof | 重庆赛维药业有限公司 | 2024-06-04 | — | — | CN | claimed |
| EP-1273301-A2 | Pharmaceutical preparations based on active ingredients susceptible to illicit administration | ALTERGON S.A. (CH) | 2003-01-08 | — | — | EP | claimed |
| WO-2002085297-A2 | COMPOSITIONS & FORMULATIONS WITH A NON-GLUCOCORTICOID STEROID &/OR A UBIQUINONE & KIT FOR TREATMENT OF RESPIRATORY & LUNG DISEASE | EAST CAROLINA UNIVERSITY (US) | 2002-10-31 | — | — | WO | claimed |
| US-6433225-B1 | REACTING A OXIME WITH 2-CHLOROETHYLAMINE HYDROCHLORIDE | SUN PHARAMACEUTICAL INDUSTRIES, LTD. (IN) | 2002-08-13 | — | — | US | claimed |
| US-6395788-B1 | FATIGUE, CHRONIC FATIGUE SYNDROME, PAIN, AND AUTOIMMUNE DISEASE TREATMENT; SIDE EFFECT REDUCTION | VELA PHARMACEUTICALS, INC. | 2002-05-28 | — | — | US | claimed |
| EP-1202721-A1 | CYCLOBENZAPRINE FOR TREATING GENERALIZED ANXIETY DISORDER AND COMPOSITIONS THEREOF | Vela Pharmaceuticals Inc. (US) | 2002-05-08 | — | — | EP | claimed |
| US-6358944-B1 | ADMINISTERING CYCLOBENZAPRINE OR METABOLITE; SIDE EFFECT REDUCTION | VELA PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | claimed |
| US-20010046988-A1 | Methods and compositions for treating or preventing sleep disturbances and associated illnesses using very low doses of cyclobenzaprine | VELA PHARMACEUTICALS, INC. | 2001-11-29 | — | — | US | claimed |
| WO-2001012174-A1 | CYCLOBENZAPRINE FOR TREATING GENERALIZED ANXIETY DISORDER AND COMPOSITIONS THEREOF | VELA PHARMACEUTICALS INC. (US) | 2001-02-22 | — | — | WO | claimed |
| US-5795895-A | Combination anorexiant drug therapy for obesity using phentermine and an SSRI drug | ANCHORS J MICHAEL (US) | 1998-08-18 | — | — | US | claimed |
| WO-1992018005-A1 | METHOD OF TREATING TRICHOTILLOMANIA AND ONYCHOPHAGIA | NATIONAL INSTITUTES OF HEALTH (US) | 1992-10-29 | — | — | WO | claimed |