Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.61 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522513 | 0.92 | MAPK14 (0.66) | MAPK14PTGER1ROCK2MAPK12MAPK11 | |
| SCHEMBL3524629 | 0.92 | MAPK14 (0.73) | MAPK14PTGER1ROCK2MAPK12MAPK11 | |
| SCHEMBL3525431 | 0.91 | MAPK14 (0.59) | MAPK14PTGER1ROCK2MAPK12MAPK11 | |
| SCHEMBL3525960 | 0.89 | MAPK14 (0.59) | MAPK14PTGER1 | |
| SCHEMBL3521891 | 0.89 | MAPK14 (0.71) | MAPK14PTGER1 | |
| SCHEMBL3525009 | 0.89 | MAPK14 (0.61) | MAPK14PTGER1 | |
| SCHEMBL3525844 | 0.89 | MAPK14 (0.62) | MAPK14PTGER1ROCK2MAPK12MAPK11 | |
| SCHEMBL3523025 | 0.88 | MAPK14 (0.59) | MAPK14PTGER1ROCK2MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL3526710 | 0.88 | MAPK14 (0.59) | MAPK14PTGER1ROCK2MAPK12MAPK11 | |
| SCHEMBL3525473 | 0.86 | MAPK14 (0.57) | MAPK14PTGER1MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795271-B2 | Substituted pyrimidinones | PHARMACIA CORPORATION (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090306108-A1 | SUBSTITUTED PYRIMIDINONES | PFIZER INC | 2009-12-10 | — | — | US | disclosed |
| US-20070167621-A1 | SUBSTITUTED PYRIMIDINONES | PHARMACIA CORPORATION (US) | 2007-07-19 | — | — | US | disclosed |
| US-7183287-B2 | Substituted pyrimidinones | PHARMACIA CORPORATION (US) | 2007-02-27 | — | — | US | disclosed |
| US-20040242608-A1 | Substituted pyrimidinones | PHARMACIA LLC | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306108-A1 | SUBSTITUTED PYRIMIDINONES | MAPK1, MAP3K8, MAP3K7 | MAPK14 38/4885PTGER1 245/4885ROCK2 443/4885 |
| US-20040242608-A1 | Substituted pyrimidinones | MAPK1, MAPK7, MAP3K8 | MAPK14 29/4885PTGER1 215/4885ROCK2 409/4885 |
| US-20070167621-A1 | SUBSTITUTED PYRIMIDINONES | MAPK1, MAP3K8, MAP3K7 | MAPK14 38/4885PTGER1 245/4885ROCK2 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.