Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 8/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3518688 | 0.91 | IKBKB (0.63) | IKBKBCHUKJAK2JAK3PIK3CA | |
| SCHEMBL3520471 | 0.88 | IKBKB (0.59) | IKBKBCHUKJAK2CDK4CDK2 | |
| SCHEMBL3519683 | 0.87 | CDK4 (0.53) | IKBKBCHUKJAK2CDK4CDK2 | |
| SCHEMBL3516458 | 0.86 | POLB (0.59) | IKBKBCHUKJAK2CDK4CDK2 | |
| SCHEMBL4383503 | 0.80 | JAK2 (0.73) | JAK2CDK2JAK3PIK3CAPIK3CB | |
| SCHEMBL11531177 | 0.79 | KMT2A (0.67) | MEN1KMT2A | |
| SCHEMBL3521975 | 0.79 | POLB (0.54) | IKBKBCHUKJAK2CDK4CDK2 | |
| SCHEMBL3522502 | 0.79 | IKBKB (0.66) | IKBKBCHUKCDK4CDK2PIK3CA | |
| SCHEMBL3522456 | 0.79 | IKBKB (0.73) | IKBKBCHUKPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3516669 | 0.78 | JAK2 (0.49) | IKBKBCHUKJAK2CDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |