Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 12/20 | 0.72 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13546172 | 1.00 | PTGER4 (0.72) | PTGER4PTGER3PTGER1KDM4EALDH1A1 | |
| SCHEMBL3526018 | 1.00 | PTGER4 (0.72) | PTGER4PTGER3PTGER1KDM4EALDH1A1 | |
| SCHEMBL12855968 | 0.95 | PTGER4 (0.66) | PTGER4PTGER3PTGER1MGLLABCB11 | |
| SCHEMBL14172619 | 0.92 | PTGER4 (0.61) | PTGER4PTGER3PTGER1MGLL | |
| SCHEMBL3529090 | 0.91 | PTGER4 (0.70) | PTGER4PTGER3PTGER1MGLL | |
| SCHEMBL13546161 | 0.91 | PTGER4 (0.70) | PTGER4PTGER3PTGER1MGLL | |
| SCHEMBL3529093 | 0.91 | PTGER4 (0.70) | PTGER4PTGER3PTGER1MGLL | |
| SCHEMBL12855966 | 0.90 | PTGER4 (0.60) | PTGER4PTGER3PTGER1ALDH1A1MGLL | |
| SCHEMBL3527515 | 0.89 | PTGER4 (0.59) | PTGER4PTGER3PTGER1KDM4EALDH1A1 | |
| SCHEMBL3527517 | 0.89 | PTGER4 (0.59) | PTGER4PTGER3PTGER1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169807-B2 | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists | ALLERGAN, INC. (US) | 2007-01-30 | — | — | US | claimed |
| US-20050228185-A1 | For therapy of asthma, dysmenorrhea, osteoporosis, bone disorders, constipation, renal disorders, sexual dysfunction, baldness, acute hepatitis, bronchitis, burn, chronic obstructive respiratory diseases, Crohn's disease, digestive ulcer, hemophagous syndrome, hepatopathy, hypercytokinemia at dialysis | ALLERGAN, INC. (US) | 2005-10-13 | — | — | US | claimed |
| US-7652063-B2 | For therapy of asthma, dysmenorrhea, osteoporosis, bone disorders, constipation, renal disorders, sexual dysfunction, baldness, acute hepatitis, bronchitis, burn, chronic obstructive respiratory diseases, Crohn's disease, digestive ulcer, hemophagous syndrome, hepatopathy, hypercytokinemia at dialysis | ALLERGAN, INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7169807-B2 | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists | ALLERGAN, INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169807-B2 | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists | ALLERGAN, INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-20070010495-A1 | 10-HYDROXY-11-DIHYDROPROSTAGLANDIN ANALOGS AS SELECTIVE EP4 AGONISTS | ALLERGAN, INC. (US) | 2007-01-11 | — | — | US | disclosed |
| US-20070010495-A1 | 10-HYDROXY-11-DIHYDROPROSTAGLANDIN ANALOGS AS SELECTIVE EP4 AGONISTS | ALLERGAN, INC. (US) | 2007-01-11 | — | — | US | disclosed |
| US-20050228185-A1 | For therapy of asthma, dysmenorrhea, osteoporosis, bone disorders, constipation, renal disorders, sexual dysfunction, baldness, acute hepatitis, bronchitis, burn, chronic obstructive respiratory diseases, Crohn's disease, digestive ulcer, hemophagous syndrome, hepatopathy, hypercytokinemia at dialysis | ALLERGAN, INC. (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228185-A1 | For therapy of asthma, dysmenorrhea, osteoporosis, bone disorders, constipation, renal disorders, sexual dysfunction, baldness, acute hepatitis, bronchitis, burn, chronic obstructive respiratory diseases, Crohn's disease, digestive ulcer, hemophagous syndrome, hepatopathy, hypercytokinemia at dialysis | CRHR2, HRH4, CNR2 | PTGER4 10/4885PTGER3 32/4885PTGER1 61/4885 |
| US-20070010495-A1 | 10-HYDROXY-11-DIHYDROPROSTAGLANDIN ANALOGS AS SELECTIVE EP4 AGONISTS | PTGER4, PTGER2, PTGER1 | PTGER4 1/4885PTGER3 9/4885PTGER1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.