Sugi Predict

Sugi Predict / Compounds / SCHEMBL3528978

SCHEMBL3528978

SCHEMBL3528978

CNC(=O)C=Cc1cnc(N)c2c(-c3cccc(Cl)c3)csc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 10/20 0.67
▸ AURKB Q96GD4 7/20 0.67
▸ LCK P06239 7/20 0.67
▸ PLK4 O00444 6/20 0.67
▸ FYN P06241 6/20 0.67
▸ CSF1R P07333 6/20 0.67
▸ LYN P07948 6/20 0.67
▸ FGFR1 P11362 6/20 0.67
▸ SRC P12931 6/20 0.67
▸ FGFR3 P22607 6/20 0.67
▸ RPS6KB1 P23443 6/20 0.67
▸ CSNK1D P48730 6/20 0.67
▸ BLK P51451 6/20 0.67
▸ NEK2 P51955 6/20 0.67
▸ STK3 Q13188 6/20 0.67
▸ MARK2 Q7KZI7 6/20 0.67
▸ PRKD2 Q9BZL6 6/20 0.67
▸ LIMK1 P53667 5/20 0.67
▸ MAP4K4 O95819 5/20 0.67
▸ FLT1 P17948 5/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3528976 1.00 KDR (0.67) KDRAURKBLCKPLK4FYN
SCHEMBL3526456 0.90 KDR (0.69) KDRAURKBLCKPLK4FYN
SCHEMBL3526450 0.90 KDR (0.69) KDRAURKBLCKPLK4FYN
SCHEMBL3528009 0.89 KDR (0.76) KDRAURKBLCKPLK4FYN
SCHEMBL3528012 0.89 KDR (0.76) KDRAURKBLCKPLK4FYN
SCHEMBL3529684 0.88 KDR (0.68) KDRAURKBLCKPLK4FYN
SCHEMBL3529678 0.88 KDR (0.68) KDRAURKBLCKPLK4FYN
SCHEMBL3566441 0.88 KDR (0.68) KDRAURKBLCKPLK4FYN
SCHEMBL3566435 0.88 KDR (0.68) KDRAURKBLCKPLK4FYN
SCHEMBL3530442 0.87 KDR (0.67) KDRAURKBLCKPLK4FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8273736-B2 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES (US) 2012-09-25 — — US disclosed
US-7737160-B2 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES INC. (US) 2010-06-15 — — US disclosed
US-20100069371-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABBOTT LABORATORIES (US) 2010-03-18 — — US disclosed
US-20070155776-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABBVIE INC. 2007-07-05 — — US disclosed
US-7202363-B2 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES (US) 2007-04-10 — — US disclosed
US-20050043347-A1 Thienopyridine and furopyridine kinase inhibitors ABBVIE INC. 2005-02-24 — — US disclosed
US-20050026944-A1 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES 2005-02-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050026944-A1 Thienopyridine and furopyridine kinase inhibitors ABL1, ERBB2, LCK KDR 494/4885AURKB 171/4885LCK 3/4885
US-20050043347-A1 Thienopyridine and furopyridine kinase inhibitors ABL1, ERBB2, LCK KDR 494/4885AURKB 171/4885LCK 3/4885
US-20100069371-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABL1, ERBB2, LCK KDR 494/4885AURKB 171/4885LCK 3/4885
US-20070155776-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABL1, ERBB2, LCK KDR 494/4885AURKB 171/4885LCK 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.