Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.65 |
| ▸ | KIT | P10721 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 5/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3525957 | 0.85 | MAPK14 (0.84) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3523996 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3526283 | 0.82 | MAPK14 (0.72) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3526077 | 0.81 | MAPK14 (0.74) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3525332 | 0.79 | MAPK14 (0.70) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL13546255 | 0.79 | MAPK14 (0.70) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3522859 | 0.79 | MAPK14 (1.00) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3523868 | 0.78 | MAPK14 (0.67) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3525660 | 0.78 | MAPK13 (0.85) | MAPK14MAPK13KITKDRLCK | |
| SCHEMBL3524620 | 0.77 | MAPK13 (0.83) | MAPK14MAPK13KITKDRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642276-B2 | Fused heteroaryl derivatives for use as P38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-05 | — | — | US | claimed |