⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12471084 | 0.65 | — | — | |
| SCHEMBL12471446 | 0.65 | — | — | |
| SCHEMBL13804080 | 0.61 | — | — | |
| SCHEMBL12470773 | 0.60 | — | — | |
| SCHEMBL24511041 | 0.56 | — | — | |
| SCHEMBL873618 | 0.56 | — | — | |
| SCHEMBL12570744 | 0.56 | — | — | |
| SCHEMBL1465460 | 0.55 | — | — | |
| Benzene SCHEMBL29202409 | 0.53 | — | — | |
| SCHEMBL890278 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128373-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2014-05-08 | — | — | US | claimed |
| CN-103517710-A | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC | 2014-01-15 | — | — | CN | claimed |
| EP-2672967-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | Plexxikon, Inc. (US) | 2013-12-18 | — | — | EP | claimed |
| WO-2012109075-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2012-08-16 | — | — | WO | claimed |
| US-20230277534-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2023-09-07 | — | — | US | disclosed |
| US-11337976-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2022-05-24 | — | — | US | disclosed |
| EP-2672967-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-10-17 | — | — | EP | disclosed |
| US-20170157120-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2017-06-08 | — | — | US | disclosed |
| US-9624213-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-20140128373-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2014-05-08 | — | — | US | disclosed |
| CN-103517710-A | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC | 2014-01-15 | — | — | CN | disclosed |
| EP-2672967-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | Plexxikon, Inc. (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012109075-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2012-08-16 | — | — | WO | disclosed |
| US-7652047-B2 | Phenylamino isothiazole carboxamidines as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20080306063-A1 | PHENYLAMINO ISOTHIAZOLE CARBOXAMIDINES AS MEK INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-12-11 | — | — | US | disclosed |
| US-7429667-B2 | Phenylamino isothiazole carboxamidines as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2006133417-A1 | PHENYLAMINO ISOTHIAZOLE CARBOXAMIDINES AS MEK INHIBITORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2006-12-14 | — | — | WO | disclosed |
| US-20060194802-A1 | Phenylamino isothiazole carboxamidines as MEK inhibitors | ARDEA BIOSCIENCES, INC. | 2006-08-31 | — | — | US | disclosed |