SCHEMBL3530204

SCHEMBL3530204

O=C(O)COc1ccc(SCCCc2ccc(-c3ccc(CCCSc4ccc(OCC(=O)O)cc4)c(C(F)(F)F)c3)cc2C(F)(F)F)cc1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 11/20 0.43
PPARG P37231 1/20 0.43
PPARA Q07869 2/20 0.43
PTGDR2 Q9Y5Y4 1/20 0.42
FFAR4 Q5NUL3 2/20 0.41
MCL1 Q07820 1/20 0.41
PLA2G2A P14555 1/20 0.41
PLA2G4B P0C869 1/20 0.40
PLA2G4A P47712 1/20 0.40
AGER Q15109 1/20 0.40
TSHR P16473 1/20 0.40
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3534807 0.88 FFAR4 (0.49) PPARDPPARGPPARAPTGDR2FFAR4
SCHEMBL3533093 0.85 PPARD (0.55) PPARDPPARGPPARA
SCHEMBL3536524 0.85 PPARD (0.49) PPARDPPARGPPARAPTGDR2TSHR
SCHEMBL3537092 0.80 PPARD (0.50) PPARDPPARGPPARA
SCHEMBL6273088 0.77 PPARD (0.41) PPARDPPARGPPARAPTGDR2RXRA
SCHEMBL3532663 0.76 PPARD (0.60) PPARDPPARGPPARA
SCHEMBL13114000 0.75 PPARD (0.37) PPARDPPARGPPARAFFAR4RXRA
SCHEMBL3531677 0.75 PPARD (0.48) PPARDPPARGPPARA
SCHEMBL3534420 0.74 PPARD (0.49) PPARDPPARGPPARAPTGDR2RXRA
SCHEMBL3533449 0.73 TDP1 (0.43) PPARDPPARAPTGDR2RXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816385-B2 Dimeric dicarboxylic acid derivatives, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2010-10-19 US claimed
US-20040259950-A1 Novel compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC 2004-12-23 US claimed
US-7816385-B2 Dimeric dicarboxylic acid derivatives, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2010-10-19 US disclosed
US-20040259950-A1 Novel compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC 2004-12-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040259950-A1 Novel compounds, their preparation and use PPARG, PPARA, PPARD PPARD 3/4885PPARG 1/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.