Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.73 |
| ▸ | FLT1 | P17948 | 13/20 | 0.73 |
| ▸ | CSF1R | P07333 | 12/20 | 0.73 |
| ▸ | LCK | P06239 | 11/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.73 |
| ▸ | KIT | P10721 | 11/20 | 0.73 |
| ▸ | FLT3 | P36888 | 10/20 | 0.73 |
| ▸ | AURKA | O14965 | 10/20 | 0.73 |
| ▸ | ABL1 | P00519 | 10/20 | 0.73 |
| ▸ | MET | P08581 | 10/20 | 0.73 |
| ▸ | NEK2 | P51955 | 10/20 | 0.73 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.73 |
| ▸ | NTRK2 | Q16620 | 10/20 | 0.73 |
| ▸ | FLT4 | P35916 | 10/20 | 0.73 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.73 |
| ▸ | PLK4 | O00444 | 9/20 | 0.73 |
| ▸ | INSR | P06213 | 9/20 | 0.73 |
| ▸ | LYN | P07948 | 9/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 9/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3526539 | 0.92 | KDR (0.70) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL27640513 | 0.91 | KDR (0.74) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3529372 | 0.91 | KDR (0.77) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3531752 | 0.90 | KDR (0.72) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3535176 | 0.89 | KDR (0.69) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3614665 | 0.89 | KDR (0.69) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3528472 | 0.89 | KDR (0.65) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3524733 | 0.89 | KDR (0.80) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3532623 | 0.88 | CSF1R (0.70) | KDRFLT1CSF1RLCKFGFR1 | |
| SCHEMBL3531308 | 0.88 | KDR (0.80) | KDRFLT1CSF1RLCKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273736-B2 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES (US) | 2012-09-25 | — | — | US | disclosed |
| US-7737160-B2 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2010-06-15 | — | — | US | disclosed |
| US-20100069371-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-03-18 | — | — | US | disclosed |
| EP-1648905-B1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBOTT LAB (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20070155776-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBVIE INC. | 2007-07-05 | — | — | US | disclosed |
| US-7202363-B2 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050043347-A1 | Thienopyridine and furopyridine kinase inhibitors | ABBVIE INC. | 2005-02-24 | — | — | US | disclosed |
| US-20050026944-A1 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026944-A1 | Thienopyridine and furopyridine kinase inhibitors | ABL1, ERBB2, LCK | KDR 494/4885FLT1 613/4885CSF1R 1197/4885 |
| US-20050043347-A1 | Thienopyridine and furopyridine kinase inhibitors | ABL1, ERBB2, LCK | KDR 494/4885FLT1 613/4885CSF1R 1197/4885 |
| US-20100069371-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABL1, ERBB2, LCK | KDR 494/4885FLT1 613/4885CSF1R 1197/4885 |
| US-20070155776-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABL1, ERBB2, LCK | KDR 494/4885FLT1 613/4885CSF1R 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.