Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 11/20 | 0.52 |
| ▸ | CSF1R | P07333 | 4/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | KIF5B | P33176 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27477737 | 0.92 | CSF1R (0.60) | AURKBIRAK4EGFRCSF1RPDGFRA | |
| SCHEMBL3534089 | 0.92 | EGFR (0.51) | AURKBIRAK4EGFRCSF1RPDGFRA | |
| SCHEMBL3533697 | 0.92 | EGFR (0.51) | AURKBIRAK4EGFRCSF1RPDGFRA | |
| SCHEMBL3529627 | 0.90 | CSF1R (0.53) | AURKBIRAK4EGFRCSF1RPDGFRA | |
| Hydrochloric Acid SCHEMBL3533954 | 0.87 | EGFR (0.55) | AURKBIRAK4EGFRCSF1RPDGFRA | |
| SCHEMBL3531811 | 0.85 | AURKB (0.58) | AURKBIRAK4EGFRCSF1RPDGFRA | |
| SCHEMBL3533218 | 0.85 | AURKB (0.53) | AURKBEGFRCSF1RPDGFRAPDGFRB | |
| SCHEMBL28842308 | 0.84 | CSF1R (0.53) | AURKBEGFRCSF1RPDGFRAPDGFRB | |
| SCHEMBL3531491 | 0.83 | CSF1R (0.49) | AURKBIRAK4EGFRCSF1RPDGFRA | |
| SCHEMBL3534428 | 0.83 | EGFR (0.45) | AURKBIRAK4EGFRCSF1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |