Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 9/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 9/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3761579 | 0.85 | TTBK1 (0.55) | EGFRAURKBTTBK1TTBK2 | |
| SCHEMBL3533225 | 0.82 | EGFR (0.70) | EGFRAURKBINCENPTTBK1TTBK2 | |
| SCHEMBL12391456 | 0.82 | TTBK1 (0.56) | EGFRTTBK1TTBK2MAPT | |
| SCHEMBL13058088 | 0.80 | TTBK1 (0.45) | EGFRAURKBTTBK1TTBK2 | |
| SCHEMBL3757431 | 0.78 | TTBK1 (0.62) | EGFRTTBK1TTBK2MAPT | |
| SCHEMBL3767014 | 0.77 | BTK (0.52) | EGFRAURKBINCENPRET | |
| SCHEMBL3770474 | 0.77 | EGFR (0.52) | EGFRAURKBINCENPROCK2RET | |
| SCHEMBL3767827 | 0.77 | CDK8 (0.50) | AURKBRET | |
| SCHEMBL3762938 | 0.77 | RET (0.60) | AURKBTTBK1ROCK2MAP4K4GSK3B | |
| SCHEMBL3763767 | 0.77 | NTRK1 (0.51) | AURKBTTBK1TTBK2RETBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662827-B2 | Pyrazole derivatives having tyrosine kinase inhibitory activity | MERCK PATENT GMBH (DE) | 2010-02-16 | — | — | US | disclosed |
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | TIE1, FER, ROS1 | EGFR 319/4885AURKB 261/4885INCENP 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.