Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.68 |
| ▸ | CDK2 | P24941 | 20/20 | 0.68 |
| ▸ | FLT3 | P36888 | 20/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575796 | 0.91 | CCNE1 (0.61) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3019793 | 0.89 | CCNE1 (0.67) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3025496 | 0.88 | CCNE1 (0.80) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3025499 | 0.88 | CCNE1 (0.80) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3025251 | 0.85 | CDK2 (0.78) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3025250 | 0.85 | CDK2 (0.78) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3023881 | 0.85 | CCNE1 (0.69) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3023887 | 0.85 | CCNE1 (0.69) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3526246 | 0.84 | CDK2 (0.71) | CCNE1CDK2FLT3KIT | |
| SCHEMBL3526251 | 0.84 | CDK2 (0.71) | CCNE1CDK2FLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-B1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2013-02-13 | — | — | EP | disclosed |
| US-7723336-B2 | Fused heterocyclic compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-05-25 | — | — | US | disclosed |