Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.63 |
| ▸ | SRC | P12931 | 1/20 | 0.63 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.62 |
| ▸ | ACHE | P22303 | 5/20 | 0.56 |
| ▸ | BACE1 | P56817 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | FLT1 | P17948 | 3/20 | 0.51 |
| ▸ | FLT4 | P35916 | 3/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954618 | 0.89 | ENPP1 (0.65) | KDRSRCENPP1ACHEBACE1 | |
| SCHEMBL3949228 | 0.89 | ENPP1 (0.65) | KDRSRCENPP1ACHEBACE1 | |
| SCHEMBL2188204 | 0.88 | ENPP1 (0.64) | KDRENPP1EGFRFGFR1FLT1 | |
| SCHEMBL2190137 | 0.88 | ENPP1 (0.64) | KDRENPP1EGFRFGFR1FLT1 | |
| SCHEMBL5223934 | 0.85 | ENPP1 (0.60) | KDRENPP1ACHEBACE1EGFR | |
| SCHEMBL1401681 | 0.81 | ENPP1 (0.64) | KDRENPP1EGFRFGFR1FLT1 | |
| SCHEMBL30017110 | 0.81 | EGFR (0.66) | KDRSRCENPP1EGFRFGFR1 | |
| SCHEMBL1613217 | 0.81 | EGFR (0.66) | KDRSRCENPP1EGFRFGFR1 | |
| SCHEMBL18744742 | 0.81 | ENPP1 (0.67) | KDRENPP1EGFRFGFR1FLT1 | |
| SCHEMBL4178028 | 0.81 | ENPP1 (0.67) | KDRENPP1EGFRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |