Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.78 |
| ▸ | AURKA | O14965 | 2/20 | 0.78 |
| ▸ | EGFR | P00533 | 6/20 | 0.74 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 10/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529625 | 0.95 | AURKB (0.86) | AURKBAURKAEGFRIRAK4KDR | |
| Trifluoroacetic Acid SCHEMBL20494312 | 0.88 | EGFR (0.72) | AURKBAURKAEGFRIRAK4KDR | |
| Anilinoquinazoline1 SCHEMBL30195580 | 0.88 | AURKB (1.00) | AURKBAURKAEGFRIRAK4KDR | |
| Anilinoquinazoline1 SCHEMBL1066538 | 0.88 | AURKB (1.00) | AURKBAURKAEGFRIRAK4KDR | |
| Anilinoquinazoline1 SCHEMBL3968007 | 0.87 | AURKB (0.98) | AURKBAURKAEGFRIRAK4KDR | |
| SCHEMBL3527097 | 0.87 | AURKB (0.82) | AURKBAURKAEGFRIRAK4KDR | |
| SCHEMBL8933899 | 0.85 | AURKB (0.94) | AURKBAURKAEGFRIRAK4KDR | |
| SCHEMBL10152557 | 0.85 | AURKA (0.69) | AURKBAURKAEGFRIRAK4KDR | |
| SCHEMBL3530823 | 0.85 | AURKB (1.00) | AURKBAURKAEGFRIRAK4KDR | |
| Hydrochloric Acid SCHEMBL8807597 | 0.84 | AURKB (0.92) | AURKBAURKAEGFRIRAK4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |