Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.45 |
| ▸ | RAF1 | P04049 | 5/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | BAX | Q07812 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3533411 | 0.89 | HTT (0.50) | HTTRECQLMAP2K1RAF1ALDH1A1 | |
| SCHEMBL5940997 | 0.88 | HTT (0.46) | HTTRECQLMAP2K1RAF1ALDH1A1 | |
| SCHEMBL5941099 | 0.88 | HTT (0.64) | HTTRECQLMAP2K1ALDH1A1LMNA | |
| SCHEMBL3527060 | 0.87 | HTT (0.68) | HTTRECQLMAP2K1ALDH1A1LMNA | |
| SCHEMBL2436285 | 0.84 | HTT (0.49) | HTTRECQLALDH1A1LMNAPOLB | |
| SCHEMBL5941105 | 0.82 | HTT (0.53) | HTTRECQLMAP2K1ALDH1A1LMNA | |
| SCHEMBL5941004 | 0.82 | HTT (0.53) | HTTRECQLMAP2K1ALDH1A1LMNA | |
| SCHEMBL5941002 | 0.82 | HTT (0.53) | HTTRECQLMAP2K1ALDH1A1LMNA | |
| SCHEMBL5941041 | 0.81 | HTT (0.52) | HTTRECQLMAP2K1ALDH1A1LMNA | |
| SCHEMBL21917165 | 0.80 | HTT (0.48) | HTTRECQLALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652047-B2 | Phenylamino isothiazole carboxamidines as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20080306063-A1 | PHENYLAMINO ISOTHIAZOLE CARBOXAMIDINES AS MEK INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-12-11 | — | — | US | disclosed |
| US-7429667-B2 | Phenylamino isothiazole carboxamidines as MEK inhibitors | ARDEA BIOSCIENCES, INC. (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2006133417-A1 | PHENYLAMINO ISOTHIAZOLE CARBOXAMIDINES AS MEK INHIBITORS | VALEANT PHARMACEUTICALS INTERNATIONAL (US) | 2006-12-14 | — | — | WO | disclosed |
| US-20060194802-A1 | Phenylamino isothiazole carboxamidines as MEK inhibitors | ARDEA BIOSCIENCES, INC. | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306063-A1 | PHENYLAMINO ISOTHIAZOLE CARBOXAMIDINES AS MEK INHIBITORS | BRAF, MAP4K2, MAP3K4 | HTT 2444/4885RECQL 4467/4885MAP2K1 45/4885 |
| US-20060194802-A1 | Phenylamino isothiazole carboxamidines as MEK inhibitors | BRAF, MAP4K2, MAP3K4 | HTT 2444/4885RECQL 4467/4885MAP2K1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.