Sugi Predict

Sugi Predict / Compounds / SCHEMBL3532902

SCHEMBL3532902

SCHEMBL3532902

COc1cc(-c2csc3ccnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ LCK P06239 20/20 1.00
▸ HCK P08631 13/20 0.73
▸ FYN P06241 2/20 0.64
▸ LYN P07948 2/20 0.64
▸ FGR P09769 2/20 0.64
▸ SRC P12931 2/20 0.64
▸ TEK Q02763 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3527019 0.86 LCK (1.00) LCKHCKFYNLYNFGR
SCHEMBL3530906 0.86 LCK (0.88) LCKHCKFYNLYNFGR
SCHEMBL3528952 0.85 LCK (0.83) LCKHCKFYNLYNFGR
SCHEMBL3526665 0.84 LCK (0.89) LCKHCKFYNLYNFGR
SCHEMBL3528483 0.84 LCK (1.00) LCKHCKFYNLYNFGR
SCHEMBL3531598 0.84 LCK (0.81) LCKHCKFYNLYNFGR
SCHEMBL3619762 0.84 LCK (0.72) LCKHCKFYNLYNFGR
SCHEMBL3531430 0.83 LCK (0.80) LCKHCKFYNLYNFGR
SCHEMBL3526701 0.83 LCK (0.82) LCKHCKFYNLYNFGR
SCHEMBL3535186 0.83 LCK (0.82) LCKHCKFYNLYNFGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8273736-B2 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES (US) 2012-09-25 — — US disclosed
US-7737160-B2 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES INC. (US) 2010-06-15 — — US disclosed
US-20100069371-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABBOTT LABORATORIES (US) 2010-03-18 — — US disclosed
EP-1648905-B1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABBOTT LAB (US) 2008-12-31 — — EP disclosed
US-20070155776-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABBVIE INC. 2007-07-05 — — US disclosed
US-7202363-B2 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES (US) 2007-04-10 — — US disclosed
US-20050043347-A1 Thienopyridine and furopyridine kinase inhibitors ABBVIE INC. 2005-02-24 — — US disclosed
US-20050026944-A1 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES 2005-02-03 — — US disclosed
US-20050020619-A1 Thienopyridine kinase inhibitors ABBOTT LABORATORIES 2005-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020619-A1 Thienopyridine kinase inhibitors ABL1, MAP4K2, MAP4K5 LCK 12/4885HCK 198/4885FYN 47/4885
US-20050026944-A1 Thienopyridine and furopyridine kinase inhibitors ABL1, ERBB2, LCK LCK 3/4885HCK 212/4885FYN 31/4885
US-20050043347-A1 Thienopyridine and furopyridine kinase inhibitors ABL1, ERBB2, LCK LCK 3/4885HCK 212/4885FYN 31/4885
US-20100069371-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABL1, ERBB2, LCK LCK 3/4885HCK 212/4885FYN 31/4885
US-20070155776-A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS ABL1, ERBB2, LCK LCK 3/4885HCK 212/4885FYN 31/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.