Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Lacosamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 1.00 |
| ▸ | CA1 | P00915 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 1.00 |
| ▸ | CA3 | P07451 | 1/20 | 1.00 |
| ▸ | CA4 | P22748 | 1/20 | 1.00 |
| ▸ | CA6 | P23280 | 1/20 | 1.00 |
| ▸ | CA5A | P35218 | 1/20 | 1.00 |
| ▸ | CA7 | P43166 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 1/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lacosamide SCHEMBL225889 | 1.00 | CA12 (1.00) | CA12CA1CA2CA3CA4 | |
| Lacosamide SCHEMBL223961 | 1.00 | CA12 (1.00) | CA12CA1CA2CA3CA4 | |
| Lacosamide SCHEMBL28184085 | 0.99 | CA12 (0.97) | CA12CA1CA2CA3CA4 | |
| SCHEMBL8601669 | 0.97 | CA12 (0.94) | CA12CA1CA2CA3CA4 | |
| SCHEMBL12188319 | 0.93 | CA12 (0.87) | CA12CA1CA2CA3CA4 | |
| SCHEMBL24081395 | 0.90 | CA1 (0.82) | CA12CA1CA2CA3CA4 | |
| Lacosamide SCHEMBL12210097 | 0.90 | CA12 (0.82) | CA12CA1CA2CA3CA4 | |
| SCHEMBL527808 | 0.90 | CA12 (0.81) | CA12CA1CA2CA3CA4 | |
| SCHEMBL14931211 | 0.90 | CA12 (0.81) | CA12CA1CA2CA3CA4 | |
| SCHEMBL12168548 | 0.90 | CA12 (0.81) | CA12CA1CA2CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7733 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| US-20260137654-A1 | COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER | THE REGENTS OF THE UNIV OF CALIFORNIA (US) | 2026-05-21 | — | — | US | claimed |
| CN-122031409-A | Lacosamide sustained-release micro-tablet and preparation method thereof | 山东丰金生物医药有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260124211-A1 | COMPOSITION CONTAINING LAMOTRIGINE, AND PREPARATION METHOD AND USE THEREOF | SHANGHAI AUCTA PHARMACEUTICALS CO., LTD. (CN) | 2026-05-07 | — | — | US | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-20260115161-A1 | 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN | LAMINAR PHARMACEUTICALS S A (ES) | 2026-04-30 | — | — | US | claimed |
| US-12595237-B2 | Lamotrigine hydrate crystal form, preparation method therefor, and composition containing same | SHANGHAI AUCTA PHARMACEUTICALS CO., LTD. (CN) | 2026-04-07 | — | — | US | claimed |
| US-12594256-B2 | A19-144, A2-73 and certain anticholinesterase inhibitor compositions and method for anti-seizure therapy | ANAVEX LIFE SCIENCES CORP. (US) | 2026-04-07 | — | — | US | claimed |
| EP-4288042-B1 | COMBINATION THERAPY FOR TREATING EXECUTIVE FUNCTION DISORDERS | ANAKA PHARMACEUTICALS INC (US) | 2026-04-01 | — | — | EP | claimed |
| US-20260083706-A1 | 5HT AGONISTS FOR TREATING DISORDERS | UNIV CALIFORNIA (US) | 2026-03-26 | — | — | US | claimed |
| EP-1373300-A2 | NOVEL USE OF A PEPTIDE CLASS OF COMPOUND FOR TREATING NON NEUROPATHIC INFLAMMATORY PAIN | SCHWARZ PHARMA AG (DE) | 2004-01-02 | — | — | EP | claimed |
| US-20030171300-A1 | Treating different types and symptoms of acute and chronic pain, especially non neuropathic inflammatory pain in mammals. The pain to be treated may be e.g. chronic inflammatory pain, rheumatoid arthritis pain and/or secondary | UCB PHARMA GMBH (DE) | 2003-09-11 | — | — | US | claimed |
| EP-1243263-B1 | Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain | SANOL ARZNEI SCHWARZ GMBH (DE) | 2002-11-27 | — | — | EP | claimed |
| EP-0996435-B1 | AMINO ACID DERIVATIVES USEFUL TO TREAT STROKE | RES CORP TECHNOLOGIES INC (US) | 2002-10-02 | — | — | EP | claimed |
| WO-2002074297-A1 | NOVEL USE OF A PEPTIDE CLASS OF COMPOUND FOR TREATING ALLODYNIA OR OTHER DIFFERENT TYPES OF CHRONIC OR PHANTOM PAIN | SCHWARZ PHARMA AG (DE) | 2002-09-26 | — | — | WO | claimed |
| WO-2002074784-A2 | NOVEL USE OF A PEPTIDE CLASS OF COMPOUND FOR TREATING NON NEUROPATHIC INFLAMMATORY PAIN | SCHWARZ PHARMA AG (DE) | 2002-09-26 | — | — | WO | claimed |
| EP-1243262-A1 | Novel use of a peptide class of compound for treating non-neuropathic inflammatory pain | SCHWARZ PHARMA AG (DE) | 2002-09-25 | — | — | EP | claimed |
| EP-1243263-A1 | Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain | SCHWARZ PHARMA AG (DE) | 2002-09-25 | — | — | EP | claimed |
| EP-0888289-B1 | ANTICONVULSANT ENANTIOMERIC AMINO ACID DERIVATIVES | RES CORP TECHNOLOGIES INC (US) | 2001-06-13 | — | — | EP | claimed |
| US-6133261-A | THERAPEUTIC METHOD FOR TREATING OR PREVENTING STROKE AND OTHER ISCHEMIC DISORDERS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 2000-10-17 | — | — | US | claimed |