⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475097 | 0.85 | CHRM2 (0.58) | — | |
| SCHEMBL3534364 | 0.80 | — | — | |
| SCHEMBL3723023 | 0.78 | — | — | |
| SCHEMBL11839445 | 0.76 | — | — | |
| SCHEMBL1362084 | 0.76 | — | — | |
| SCHEMBL1868584 | 0.76 | — | — | |
| SCHEMBL3183110 | 0.76 | — | — | |
| SCHEMBL11033324 | 0.76 | CHRM2 (0.45) | — | |
| SCHEMBL8143743 | 0.74 | POLB (0.52) | — | |
| SCHEMBL9864079 | 0.73 | CHRM2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978215-A | Benzyl-protected ortho-chiral amino alcohol compound and preparation method thereof | 复旦大学 | 2020-11-24 | — | — | CN | claimed |
| CN-105722972-A | Cellular factors involved in the cytotoxicity of leukocidins of staphylococcus aureus: novel therapeutic target | 纽约大学 | 2016-06-29 | — | — | CN | claimed |
| CN-102548965-A | Substituted amide compounds | ASTELLAS PHARMA INC | 2012-07-04 | — | — | CN | claimed |
| US-20100063080-A1 | CXCR2 inhibitors | PRESS NEIL JOHN | 2010-03-11 | — | — | US | claimed |
| EP-2086947-A1 | PYRIMIDINES AND THEIR USE AS CXCR2 RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2009-08-12 | — | — | EP | claimed |
| WO-2008061740-A1 | PYRIMIDINES AND THEIR USE AS CXCR2 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2008-05-29 | — | — | WO | claimed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | claimed |
| CN-111978215-A | Benzyl-protected ortho-chiral amino alcohol compound and preparation method thereof | 复旦大学 | 2020-11-24 | — | — | CN | disclosed |
| CN-102548965-B | Substituted amide compounds | ASTELLAS PHARMA INC | 2014-04-09 | — | — | CN | disclosed |
| EP-2086960-B1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2014-03-05 | — | — | EP | disclosed |
| CN-101514168-B | Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2-furanyl) propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide | MERCK SHARP & DOHME | 2014-02-26 | — | — | CN | disclosed |
| CN-101514193-B | Synthesis of furan substituted dioxo cyclobutene | MERCK SHARP & DOHME | 2012-12-19 | — | — | CN | disclosed |
| CN-102548965-A | Substituted amide compounds | ASTELLAS PHARMA INC | 2012-07-04 | — | — | CN | disclosed |
| CN-1805947-A | Synthesis of 2-hydroxy-N, N-dimethyl-3- [ [ 2- [ [1 - (5-methyl-2-furyl) propyl ] amino ] -3, 4-dioxo-1-cyclobuten-1-yl ] amino ] benzamide | SCHERING CORP (US) | 2006-07-19 | — | — | CN | disclosed |
| CN-1247544-C | Anthranilic acid amides with heteroarylsulfonyl side chains and their use as antiarrhythmic active substances | SANNOFFE AVENTIS DEUTSCHLAND G (DE) | 2006-03-29 | — | — | CN | disclosed |
| CN-1529695-A | Anthranilic acid amides with heteroarylsulfonyl side chains, method for the production thereof, use thereof as medicaments or diagnostic agents, and pharmaceutical preparations containing said compounds | ������ҽҩ�¹�����˾ | 2004-09-15 | — | — | CN | disclosed |
| US-4333940-A | Ring-fluorinated 4-(monosubstituted-amino) phenyl compounds in inhibiting atherosclerotic lesion development | AMERICAN CYANAMID COMPANY (US) | 1982-06-08 | — | — | US | disclosed |
| US-4243609-A | ANTILIPEMIC AGENTS, ANTIATHEROSCLEROTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4085109-A | Pyridine sulfur flavoring agents | FIRMENICH & CIE (CH) | 1978-04-18 | — | — | US | disclosed |
| US-3943260-A | TETRAHYDRO-THIO-PHEN-3-ONES | FIRMENICH & CIE (CH) | 1976-03-09 | — | — | US | disclosed |