Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532065 | 0.76 | MEN1 (0.43) | HTTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3532067 | 0.75 | MEN1 (0.47) | HTTKDRGAAALDH1A1MEN1 | |
| SCHEMBL3531915 | 0.73 | MAPK1 (0.44) | KDRALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL3531061 | 0.73 | PDGFRB (0.43) | KDRALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL3534010 | 0.72 | KDM4E (0.43) | KDRALDH1A1TSHRLMNAHSD17B10 | |
| SCHEMBL3526575 | 0.71 | PPARG (0.52) | HTTKDRGAAALDH1A1MEN1 | |
| SCHEMBL3529342 | 0.71 | PDGFRB (0.45) | HTTKDRALDH1A1TSHRLMNA | |
| SCHEMBL3534370 | 0.70 | HTT (0.57) | HTTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3530137 | 0.70 | CNR2 (0.41) | KDRALDH1A1TSHRHSD17B10KDM4E | |
| SCHEMBL3531388 | 0.69 | KDR (0.47) | KDRMEN1KMT2AMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662828-B2 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds | GRUENENTHAL GMBH (DE) | 2010-02-16 | — | — | US | claimed |