Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.81 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19303194 | 0.89 | CDK8 (1.00) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3621438 | 0.89 | CDK8 (0.67) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5164195 | 0.86 | CDK8 (0.80) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL29397175 | 0.85 | CDK8 (0.78) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL20627061 | 0.80 | CDK8 (0.51) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4882965 | 0.80 | CDK8 (0.62) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1793950 | 0.80 | MAPK14 (0.58) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2706726 | 0.80 | GRN (0.57) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1600309 | 0.79 | CDK8 (0.82) | CDK8MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL21436480 | 0.79 | CDK8 (0.79) | CDK8MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662827-B2 | Pyrazole derivatives having tyrosine kinase inhibitory activity | MERCK PATENT GMBH (DE) | 2010-02-16 | — | — | US | disclosed |
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | TIE1, FER, ROS1 | CDK8 433/4885MAPK14 592/4885MAPK13 654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.