Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | F3 | P13726 | 1/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3538636 | 0.89 | HDAC1 (0.58) | HDAC1HDAC4HDAC3HDAC2HDAC7 | |
| SCHEMBL3540037 | 0.85 | HDAC1 (0.62) | HDAC1NAMPTMEN1LMNAMAPT | |
| SCHEMBL3540592 | 0.83 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL3542333 | 0.83 | HDAC1 (0.55) | HDAC1HDAC2MEN1MAPTKMT2A | |
| SCHEMBL3552457 | 0.83 | HDAC1 (0.61) | HDAC1HDAC4HDAC3HDAC2HDAC7 | |
| SCHEMBL8243120 | 0.83 | HDAC1 (0.78) | HDAC1HDAC4HDAC3HDAC2HDAC7 | |
| SCHEMBL3534283 | 0.82 | HDAC1 (0.60) | HDAC1HDAC4HDAC3HDAC2HDAC7 | |
| SCHEMBL3539213 | 0.82 | HDAC1 (0.64) | HDAC1HDAC4HDAC3HDAC2HDAC7 | |
| SCHEMBL3537745 | 0.81 | HDAC1 (0.59) | HDAC1HDAC4HDAC3HDAC2HDAC7 | |
| SCHEMBL3534645 | 0.81 | HDAC1 (0.67) | HDAC1HDAC4HDAC3HDAC2HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642275-B2 | Histone deacetylase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-01-05 | — | — | US | claimed |
| US-20060205941-A1 | Histone deacetylase inhibitors | TAKEDA SAN DIEGO, INC. | 2006-09-14 | — | — | US | claimed |
| US-7642275-B2 | Histone deacetylase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642275-B2 | Histone deacetylase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642275-B2 | Histone deacetylase inhibitors | TAKEDA SAN DIEGO, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| EP-1824831-A2 | HISTONE DEACETYLASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20060205941-A1 | Histone deacetylase inhibitors | TAKEDA SAN DIEGO, INC. | 2006-09-14 | — | — | US | disclosed |
| WO-2006066133-A2 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006066133-A2 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205941-A1 | Histone deacetylase inhibitors | HDAC1, HDAC3, HDAC5 | HDAC1 1/4885HDAC4 11/4885HDAC3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.